Nigel L Hammond
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Explore the profile of Nigel L Hammond including associated specialties, affiliations and a list of published articles.
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12
Citations
268
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Recent Articles
1.
Hammond N, Dixon M
Oral Dis
. 2022 Feb;
28(5):1306-1326.
PMID: 35226783
Clefts of the lip and palate (CLP), the major causes of congenital facial malformation globally, result from failure of fusion of the facial processes during embryogenesis. With a prevalence of...
2.
Welzenbach J, Hammond N, Nikolic M, Thieme F, Ishorst N, Leslie E, et al.
HGG Adv
. 2022 Jan;
2(3):100038.
PMID: 35047836
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common congenital facial malformation with a multifactorial etiology. Genome-wide association studies (GWASs) have identified multiple genetic risk loci. However,...
3.
Thieme F, Henschel L, Hammond N, Ishorst N, Hausen J, Adamson A, et al.
Hum Mutat
. 2021 May;
42(8):1066-1078.
PMID: 34004033
Genome-wide association studies (GWAS) have generated unprecedented insights into the genetic etiology of orofacial clefting (OFC). The moderate effect sizes of associated noncoding risk variants and limited access to disease-relevant...
4.
Hammond N, Dixon J, Dixon M
Semin Cell Dev Biol
. 2017 Aug;
91:75-83.
PMID: 28803895
Development of the secondary palate involves a complex series of embryonic events which, if disrupted, result in the common congenital anomaly cleft palate. The secondary palate forms from paired palatal...
5.
Richardson R, Mitchell K, Hammond N, Mollo M, Kouwenhoven E, Wyatt N, et al.
PLoS Genet
. 2017 Jun;
13(6):e1006828.
PMID: 28604778
Cleft palate is a common congenital disorder that affects up to 1 in 2500 live births and results in considerable morbidity to affected individuals and their families. The aetiology of...
6.
Ludwig K, Bohmer A, Bowes J, Nikolic M, Ishorst N, Wyatt N, et al.
Hum Mol Genet
. 2017 Jan;
26(4):829-842.
PMID: 28087736
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of...
7.
Kawasaki M, Kawasaki K, Oommen S, Blackburn J, Watanabe M, Nagai T, et al.
Dev Dyn
. 2016 Jun;
245(9):937-46.
PMID: 27302476
Background: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae...
8.
Richardson R, Hammond N, Coulombe P, Saloranta C, Nousiainen H, Salonen R, et al.
J Clin Invest
. 2014 Aug;
124(9):3891-900.
PMID: 25133425
Appropriate development of stratified, squamous, keratinizing epithelia, such as the epidermis and oral epithelia, generates an outer protective permeability barrier that prevents water loss, entry of toxins, and microbial invasion....
9.
Hammond N, Headon D, Dixon M
J Invest Dermatol
. 2012 Mar;
132(6):1543-53.
PMID: 22377760
The 14-3-3σ (Stratifin; Sfn) is a cell cycle regulator intimately involved in the program of epithelial keratinization. 14-3-3σ is unique in that it is expressed primarily in epithelial cells and...
10.
Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, et al.
Dev Biol
. 2012 Feb;
365(1):61-70.
PMID: 22366192
Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth,...