Kerstin U Ludwig
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Explore the profile of Kerstin U Ludwig including associated specialties, affiliations and a list of published articles.
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96
Citations
2648
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Recent Articles
1.
Schmidt A, Casadei N, Brand F, Demidov G, Vojgani E, Abolhassani A, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012786.
PMID: 39715278
Courses of SARS-CoV-2 infections are highly variable, ranging from asymptomatic to lethal COVID-19. Though research has shown that host genetic factors contribute to this variability, cohort-based joint analyses of variants...
2.
Ishorst N, Holzel S, Greve C, Yilmaz O, Lindenberg T, Lambertz J, et al.
Eur J Hum Genet
. 2024 Dec;
PMID: 39702590
Orofacial clefting (OFC) is a frequent congenital anomaly and can occur either in the context of underlying syndromes or in isolation (nonsyndromic). The two common OFC phenotypes are cleft lip...
3.
4.
Siewert A, Hoeland S, Mangold E, Ludwig K
Sci Rep
. 2024 Nov;
14(1):26492.
PMID: 39489835
Non-syndromic cleft lip with/without cleft palate (nsCL/P) is one of the most common birth defects and has a multifactorial etiology. To date, over 45 loci harboring common risk variants have...
5.
Boos J, van der Made C, Ramakrishnan G, Coughlan E, Asselta R, Loscher B, et al.
HGG Adv
. 2024 Jun;
5(4):100323.
PMID: 38944683
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52...
6.
7.
Godfrey L, Forster J, Liffers S, Schroder C, Koster J, Henschel L, et al.
Clin Epigenetics
. 2024 Jan;
16(1):13.
PMID: 38229153
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essentially...
8.
TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
De Magis A, Schult P, Schonleber A, Linke R, Ludwig K, Kummerer B, et al.
BMC Biol
. 2024 Jan;
22(1):5.
PMID: 38185627
Background: SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe...
9.
Kollges R, Stegmann J, Schneider S, Waffenschmidt L, Fazaal J, Breuer K, et al.
Biomolecules
. 2023 Jul;
13(7).
PMID: 37509153
Background: The bladder exstrophy-epispadias complex (BEEC) is a spectrum of congenital abnormalities that involves the abdominal wall, the bony pelvis, the urinary tract, the external genitalia, and, in severe cases,...
10.
Siewert A, Reiz B, Krug C, Heggemann J, Mangold E, Dickten H, et al.
Front Cell Dev Biol
. 2023 May;
11:1091666.
PMID: 37169019
Cleft lip ± cleft palate (CL/P) is one of the most common birth defects. Although research has identified multiple genetic risk loci for different types of CL/P (i.e., syndromic or...