Nicole A Edwards
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Explore the profile of Nicole A Edwards including associated specialties, affiliations and a list of published articles.
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14
Citations
103
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Recent Articles
1.
Edwards N, Rankin S, Kashyap A, Warren A, Agricola Z, Kenny A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873300
Disruptions in foregut morphogenesis can result in life-threatening conditions where the trachea and esophagus fail to separate properly, such as esophageal atresia (EA) and tracheoesophageal fistulas (TEF). The developmental basis...
2.
Powell A, Edwards N, Hunter H, Kiser P, Watson A, Cumming R, et al.
Stem Cells Dev
. 2023 May;
32(15-16):434-449.
PMID: 37183401
The ShcA adapter protein is necessary for early embryonic development. The role of ShcA in development is primarily attributed to its 52 and 46 kDa isoforms that transduce receptor tyrosine...
3.
Gipson G, Nolan K, Kattamuri C, Kenny A, Agricola Z, Edwards N, et al.
BMC Biol
. 2023 Feb;
21(1):16.
PMID: 36726183
Background: Proteins of the TGFβ family, which are largely studied as homodimers, are also known to form heterodimers with biological activity distinct from their component homodimers. For instance, heterodimers of...
4.
Zhong G, Ahimaz P, Edwards N, Hagen J, Faure C, Lu Q, et al.
HGG Adv
. 2022 Jul;
3(3):100126.
PMID: 35800210
[This corrects the article DOI: 10.1016/j.xhgg.2022.100107.].
5.
Zhong G, Ahimaz P, Edwards N, Hagen J, Faure C, Lu Q, et al.
HGG Adv
. 2022 May;
3(3):100107.
PMID: 35519826
Esophageal atresias/tracheoesophageal fistulas (EA/TEF) are rare congenital anomalies caused by aberrant development of the foregut. Previous studies indicate that rare or genetic variants significantly contribute to EA/TEF risk, and most...
6.
Edwards N, Zorn A
Curr Top Dev Biol
. 2021 Jun;
145:61-90.
PMID: 34074536
The endoderm is the innermost germ layer that forms the linings of the respiratory and gastrointestinal tracts, and their associated organs, during embryonic development. Xenopus embryology experiments have provided fundamental...
7.
Edwards N, Shacham-Silverberg V, Weitz L, Kingma P, Shen Y, Wells J, et al.
Dev Biol
. 2021 May;
477:85-97.
PMID: 34023332
Trachea-esophageal defects (TEDs), including esophageal atresia (EA), tracheoesophageal fistula (TEF), and laryngeal-tracheoesophageal clefts (LTEC), are a spectrum of life-threatening congenital anomalies in which the trachea and esophagus do not form...
8.
Naert T, Tulkens D, Edwards N, Carron M, Shaidani N, Wlizla M, et al.
Sci Rep
. 2020 Sep;
10(1):14662.
PMID: 32887910
CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double...
9.
Nasr T, Mancini P, Rankin S, Edwards N, Agricola Z, Kenny A, et al.
Dev Cell
. 2019 Dec;
51(6):665-674.e6.
PMID: 31813796
The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key signaling pathways such as Hedgehog (HH)/Gli can disrupt tracheoesophageal (TE)...
10.
Esseltine J, Brooks C, Edwards N, Subasri M, Sampson J, Seguin C, et al.
Stem Cells
. 2019 Oct;
38(1):52-66.
PMID: 31646713
Characterization of the pluripotent "ground state" has led to a greater understanding of species-specific stem cell differences and has imparted an appreciation of the pluripotency continuum that exists in stem...