Matthew J Kofron
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Explore the profile of Matthew J Kofron including associated specialties, affiliations and a list of published articles.
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4
Citations
79
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Recent Articles
1.
Hendrickson C, Blitz I, Hussein A, Paraiso K, Cho J, Klymkowsky M, et al.
bioRxiv
. 2025 Jan;
PMID: 39829826
In vertebrates, germ layer specification represents a critical transition where pluripotent cells acquire lineage-specific identities. We identify the maternal transcription factors Foxi2 and Sox3 to be pivotal master regulators of...
2.
Edwards N, Rankin S, Kashyap A, Warren A, Agricola Z, Kenny A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873300
Disruptions in foregut morphogenesis can result in life-threatening conditions where the trachea and esophagus fail to separate properly, such as esophageal atresia (EA) and tracheoesophageal fistulas (TEF). The developmental basis...
3.
Nasr T, Mancini P, Rankin S, Edwards N, Agricola Z, Kenny A, et al.
Dev Cell
. 2019 Dec;
51(6):665-674.e6.
PMID: 31813796
The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key signaling pathways such as Hedgehog (HH)/Gli can disrupt tracheoesophageal (TE)...
4.
Lee K, McCauley H, Broda T, Kofron M, Wells J, Hong C
Lab Chip
. 2018 Sep;
18(20):3079-3085.
PMID: 30238091
Current in vitro approaches and animal models have critical limitations for modeling human gastrointestinal diseases because they may not properly represent multicellular human primary tissues. Therefore, there is a need...
5.
Schumacher J, Zhao E, Kofron M, Sumanas S
Biotechniques
. 2014 Nov;
57(5):254-6.
PMID: 25391914
Two-color fluorescent in situ hybridization (FISH) is a widely used technique for comparing relative gene expression patterns. Current two-color FISH protocols are not ideal for detecting weakly expressed transcripts or...