Nicolas Probst
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Explore the profile of Nicolas Probst including associated specialties, affiliations and a list of published articles.
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7
Citations
46
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Recent Articles
1.
Dutheuil G, Oukoloff K, Korac J, Lenoir F, El Bousmaqui M, Probst N, et al.
J Med Chem
. 2025 Jan;
68(3):2981-3003.
PMID: 39883878
METTL3 is the RNA methyltransferase predominantly responsible for the addition of N-methyladenosine (mA), the most abundant modification to mRNA. The prevalence of mA and the activity and expression of METTL3...
2.
Da Silva O, Probst N, Landry C, Hanak A, Warnault P, Coisne C, et al.
J Med Chem
. 2022 Mar;
65(6):4649-4666.
PMID: 35255209
Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of...
3.
Zorbaz T, Misetic P, Probst N, Zunec S, Zandona A, Mendas G, et al.
ACS Chem Neurosci
. 2020 Feb;
11(7):1072-1084.
PMID: 32105443
Nerve agents, the deadliest chemical warfare agents, are potent inhibitors of acetylcholinesterase (AChE) and cause rapid cholinergic crisis with serious symptoms of poisoning. Oxime reactivators of AChE are used in...
4.
Prieri M, Frita R, Probst N, Sournia-Saquet A, Bourotte M, Deprez B, et al.
Eur J Med Chem
. 2018 Sep;
159:35-46.
PMID: 30268015
Ethionamide is a key antibiotic prodrug of the second-line chemotherapy regimen to treat tuberculosis. It targets the biosynthesis of mycolic acids thanks to a mycobacterial bioactivation carried out by the...
5.
Probst N, Lartia R, Thery O, Alami M, Defrancq E, Messaoudi S
Chemistry
. 2017 Dec;
24(8):1795-1800.
PMID: 29205564
An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good...
6.
Probst N, Grelier G, Ghermani N, Gandon V, Alami M, Messaoudi S
Org Lett
. 2017 Sep;
19(19):5038-5041.
PMID: 28901149
An expedient method for the synthesis of fused glycosylquinolin-2-ones and glycosylspirooxindoles through an unprecedented intramolecular Pd-catalyzed anomeric C-H activation of the sugar moiety of 2-bromophenyl glycosylcarboxamides is reported. The scope...
7.
Probst N, Martin A, Desire J, Mingot A, Marrot J, Bleriot Y, et al.
Org Lett
. 2017 Mar;
19(5):1040-1043.
PMID: 28253629
Internal C-aryl and C-alkyl glycosides derived from 2-aminoglycopyranoses have been synthesized, exploiting a HF-mediated stereoselective intramolecular glycosylation. These conditions are compatible with acetate protecting groups and allow introduction of aromatics...
8.
Probst N, Madarasz A, Valkonen A, Papai I, Rissanen K, Neuvonen A, et al.
Angew Chem Int Ed Engl
. 2012 Jul;
51(34):8495-9.
PMID: 22777736
Hold them tight: Guided by X-ray structures, bifunctional thiourea catalysts containing an activating intramolecular hydrogen bond were redesigned. The new catalysts were used to effect a highly enantioselective Mannich reaction...