Martin J Slater
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Explore the profile of Martin J Slater including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
200
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0
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Recent Articles
1.
Dutheuil G, Oukoloff K, Korac J, Lenoir F, El Bousmaqui M, Probst N, et al.
J Med Chem
. 2025 Jan;
68(3):2981-3003.
PMID: 39883878
METTL3 is the RNA methyltransferase predominantly responsible for the addition of N-methyladenosine (mA), the most abundant modification to mRNA. The prevalence of mA and the activity and expression of METTL3...
2.
3.
Simon B, Walmsley C, Jackson V, Garvey E, Slater M, Berrisford D, et al.
Bioorg Med Chem Lett
. 2018 Nov;
29(2):339-341.
PMID: 30477891
Synthetic neamine mimetics have been evaluated for binding to the HIV-1 Rev response element. Modified neamine derivatives, obtained from reductive amination of neamine, led to identification of new 6-amino modified...
4.
Oliver J, Sibley G, Beckmann N, Dobb K, Slater M, Mcentee L, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(45):12809-12814.
PMID: 27791100
There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome...
5.
Harris C, Hill R, Sheppard D, Slater M, Stouten P
Comb Chem High Throughput Screen
. 2011 Apr;
14(6):521-31.
PMID: 21521154
Target-focused compound libraries are collections of compounds which are designed to interact with an individual protein target or, frequently, a family of related targets (such as kinases, voltage-gated ion channels,...
6.
Li X, Zhang Y, Liu Y, Ding C, Zhou Y, Li Q, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(19):5695-700.
PMID: 20801653
A novel series of P2-P4 macrocyclic HCV NS3/4A protease inhibitors with α-amino cyclic boronates as warheads at the P1 site was designed and synthesized. When compared to their linear analogs,...
7.
Li X, Zhang Y, Liu Y, Ding C, Li Q, Zhou Y, et al.
Bioorg Med Chem Lett
. 2010 May;
20(12):3550-6.
PMID: 20493689
We have designed and synthesized a novel series of alpha-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the...
8.
Jones R, Rafiq S, Elsegood M, McKee V, Slater M
Chem Asian J
. 2010 Jan;
5(3):461-5.
PMID: 20052706
No abstract available.
9.
Agbodjan A, Cooley B, Copley R, Corfield J, Flanagan R, Glover B, et al.
J Org Chem
. 2008 Mar;
73(8):3094-102.
PMID: 18358046
A practical asymmetric synthesis of a highly substituted N-acylpyrrolidine on multi-kilogram scale is described. The key step in the construction of the three stereocenters is a [3+2] cycloaddition of methyl...
10.
Burton G, Ku T, Carr T, Kiesow T, Sarisky R, Lin-Goerke J, et al.
Bioorg Med Chem Lett
. 2007 Feb;
17(7):1930-3.
PMID: 17270443
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta21 enzyme inhibitors to an example with...