Nicolas Pineault
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Explore the profile of Nicolas Pineault including associated specialties, affiliations and a list of published articles.
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Citations
754
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Recent Articles
11.
Maganti H, Bailey A, Kirkham A, Shorr R, Pineault N, Allan D
Stem Cells Transl Med
. 2021 Mar;
10(7):996-1007.
PMID: 33666363
Gene editing blood-derived cells is an attractive approach to cure selected monogenic diseases but remains experimental. A systematic search of preclinical controlled studies is needed to determine the persistence of...
12.
Jahan S, Kaushal R, Pasha R, Pineault N
Transfus Med Rev
. 2021 Feb;
35(2):95-102.
PMID: 33640254
Hematopoietic stem cell (HSC) transplantation is a well-established procedure for the treatment of many blood related malignancies and disorders. Before transplantation, HSC are collected and cryopreserved until use. The method...
13.
Hovey O, Pasha R, Lehmann Z, Pineault N
Proteomics
. 2020 Jul;
20(15-16):e2000036.
PMID: 32666692
Osteoblasts are a key component of the endosteal hematopoietic stem cell niche and are recognized with strong hematopoietic supporting activity. Similarly, mesenchymal stromal cells (MSC)-derived osteoblast (M-OST) conditioned media (OCM)...
14.
Pasha R, Howell A, Turner T, Halpenny M, Elmoazzen H, Acker J, et al.
Cytotherapy
. 2020 Jun;
22(11):690-697.
PMID: 32591113
Background Aims: Cryopreserved cord blood units (CBUs) can be exposed to transient warming events (TWEs) during routine banking operations, which may affect their potency. NetCord-FACT guidelines recommend removal of these...
15.
Jahan S, Adam M, Manesia J, Doxtator E, Ben R, Pineault N
Transfusion
. 2020 Mar;
60(4):769-778.
PMID: 32187691
Background: Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth of ice, a process referred to as ice recrystallization, is one of...
16.
Fournier D, Lewin A, Simard C, Trepanier P, Neron S, Ballerini L, et al.
Cytotherapy
. 2019 Dec;
22(1):44-51.
PMID: 31883947
Background Aims: In 2016, specifications for both pre-cryopreserved and post-thawed cord blood were defined in the sixth edition of NetCord Foundation for the Accreditation of Cellular Therapy (FACT) Standards for...
17.
Pasha R, Halpenny M, Pineault N
Vox Sang
. 2019 Oct;
114(8):876-883.
PMID: 31625187
Background And Objectives: There is no standard methodology for post-thaw sample preparation for viability analysis of umbilical cord blood units (CBU). A common challenge faced by CB bank is for...
18.
Abu-Khader A, Law K, Jahan S, Manesia J, Pasha R, Hovey O, et al.
Stem Cells
. 2018 Dec;
37(3):345-356.
PMID: 30520180
Ex vivo expansion of hematopoietic stem cell (HSCs) and progenitors may one day overcome the slow platelet engraftment kinetics associated with umbilical cord blood transplantation. Serum-free medium conditioned with osteoblasts...
19.
Briard J, Jahan S, Chandran P, Allan D, Pineault N, Ben R
ACS Omega
. 2018 Jul;
1(5):1010-1018.
PMID: 30023498
The success of hematopoietic stem cell transplantation depends in part on the number and the quality of cells transplanted. Cryoinjuries during freezing and thawing reduce the ability of hematopoietic stem...
20.
Michalicka M, Boisjoli G, Jahan S, Hovey O, Doxtator E, Abu-Khader A, et al.
Stem Cells Dev
. 2017 Oct;
26(24):1735-1748.
PMID: 29050516
Coculture of hematopoietic stem cells (HSC) with primary stromal cells from HSC niches supports the maintenance and expansion of HSC and progenitors ex vivo. However, a major drawback is the...