Nicolas Melin
Overview
Explore the profile of Nicolas Melin including associated specialties, affiliations and a list of published articles.
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10
Citations
319
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Recent Articles
1.
Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer F, Brodie T, Petit B, et al.
JHEP Rep
. 2022 Jun;
4(7):100508.
PMID: 35712694
Background & Aims: High-dose irradiation is an essential tool to help control the growth of hepatic tumors, but it can cause radiation-induced liver disease (RILD). This life-threatening complication manifests itself...
2.
Melin N, Sanchez-Taltavull D, Fahrner R, Keogh A, Dosch M, Buchi I, et al.
Cell Death Dis
. 2021 Apr;
12(4):366.
PMID: 33824326
The toll-like receptor 5 (TLR5) agonist, CBLB502/Entolimod, is a peptide derived from bacterial flagellin and has been shown to protect against radiation-induced tissue damage in animal models. Here we investigated...
3.
Sanchez-Taltavull D, Perkins T, Dommann N, Melin N, Keogh A, Candinas D, et al.
NAR Genom Bioinform
. 2021 Feb;
2(1):lqaa002.
PMID: 33575552
Assessing similarity is highly important for bioinformatics algorithms to determine correlations between biological information. A common problem is that similarity can appear by chance, particularly for low expressed entities. This...
4.
Dosch M, Zindel J, Jebbawi F, Melin N, Sanchez-Taltavull D, Stroka D, et al.
Elife
. 2019 Feb;
8.
PMID: 30735126
Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine...
5.
Thomsen A, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, et al.
Lab Chip
. 2017 Dec;
18(1):179-189.
PMID: 29211089
Multicellular spheroids represent a well-established 3D model to study healthy and diseased cells in vitro. The use of conventional 3D cell culture platforms for the generation of multicellular spheroids is...
6.
Ley S, Galuba O, Salathe A, Melin N, Aebi A, Pikiolek M, et al.
SLAS Discov
. 2017 Mar;
22(5):571-582.
PMID: 28345372
Oral and intestinal mucositis is a debilitating side effect of radiation treatment. A mouse model of radiation-induced mucositis leads to weight loss and tissue damage, reflecting the human ailment as...
7.
P2X1-regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration
Kudira R, Malinka T, Kohler A, Dosch M, Gomez de Aguero M, Melin N, et al.
Hepatology
. 2016 Feb;
63(6):2004-17.
PMID: 26853442
Unlabelled: Paracrine signalling mediated by cytokine secretion is essential for liver regeneration after hepatic resection, yet the mechanisms of cellular crosstalk between immune and parenchymal cells are still elusive. Interleukin-22...
8.
Junne T, Wong J, Studer C, Aust T, Bauer B, Beibel M, et al.
J Cell Sci
. 2015 Jan;
128(6):1217-29.
PMID: 25616894
A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated that the Sec61 translocon complex, the machinery...
9.
Trautmann F, Cojoc M, Kurth I, Melin N, Bouchez L, Dubrovska A, et al.
Int J Radiat Biol
. 2014 Mar;
90(8):687-99.
PMID: 24650104
Purpose: Radioresistance of cancer cells remains a fundamental barrier for maximum efficient radiotherapy. Tumor heterogeneity and the existence of distinct cell subpopulations exhibiting different genotypes and biological behaviors raise difficulties...
10.
Hoepfner D, Helliwell S, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, et al.
Microbiol Res
. 2013 Dec;
169(2-3):107-20.
PMID: 24360837
Due to evolutionary conservation of biology, experimental knowledge captured from genetic studies in eukaryotic model organisms provides insight into human cellular pathways and ultimately physiology. Yeast chemogenomic profiling is a...