Adrian Keogh
Overview
Explore the profile of Adrian Keogh including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
910
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Recent Articles
1.
Rossetti G, Dommann N, Karamichali A, Dionellis V, Asensio Aldave A, Yarahmadov T, et al.
Cell
. 2024 Sep;
187(22):6220-6234.e13.
PMID: 39293447
The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young...
2.
Stillinovic M, Sarangdhar M, Andina N, Tardivel A, Greub F, Bombaci G, et al.
Sci Adv
. 2024 May;
10(22):eadl0320.
PMID: 38820160
Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation....
3.
Lambrecht R, Rudolf F, Uckert A, Sladky V, Phan T, Jansen J, et al.
Cell Death Differ
. 2023 Nov;
31(1):119-131.
PMID: 38001256
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality....
4.
Yarahmadov T, Wang J, Sanchez-Taltavull D, Alvarez Rojas C, Brodie T, Buchi I, et al.
Infect Immun
. 2022 Jul;
90(8):e0017422.
PMID: 35862712
The larval stage of the helminthic cestode Echinococcus multilocularis can inflict tumor-like hepatic lesions that cause the parasitic disease alveolar echinococcosis in humans, with high mortality in untreated patients. Opportunistic...
5.
Lett M, Mehta H, Keogh A, Jaeger T, Jacquet M, Powell K, et al.
Gut
. 2022 Jan;
71(12):2526-2538.
PMID: 35058274
Objective: Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert...
6.
Sanchez-Taltavull D, Castelo-Szekely V, Murugan S, Hamley J, Rollenske T, Ganal-Vonarburg S, et al.
PLoS One
. 2021 Nov;
16(11):e0258700.
PMID: 34739484
Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal preventive strategies for healthcare workers during the COVID-19 pandemic remain poorly understood. Here...
7.
Wang Z, Keogh A, Waldt A, Cuttat R, Neri M, Zhu S, et al.
Sci Rep
. 2021 Sep;
11(1):19396.
PMID: 34588551
Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components and represents a leading cause of morbidity and mortality worldwide. Previous studies of nonalcoholic steatohepatitis...
8.
Baier F, Sanchez-Taltavull D, Yarahmadov T, Castella C, Jebbawi F, Keogh A, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Apr;
12(2):745-767.
PMID: 33866021
Background & Aims: Tight junctions in the liver are essential to maintain the blood-biliary barrier, however, the functional contribution of individual tight junction proteins to barrier and metabolic homeostasis remains...
9.
Melin N, Sanchez-Taltavull D, Fahrner R, Keogh A, Dosch M, Buchi I, et al.
Cell Death Dis
. 2021 Apr;
12(4):366.
PMID: 33824326
The toll-like receptor 5 (TLR5) agonist, CBLB502/Entolimod, is a peptide derived from bacterial flagellin and has been shown to protect against radiation-induced tissue damage in animal models. Here we investigated...
10.
Sanchez-Taltavull D, Perkins T, Dommann N, Melin N, Keogh A, Candinas D, et al.
NAR Genom Bioinform
. 2021 Feb;
2(1):lqaa002.
PMID: 33575552
Assessing similarity is highly important for bioinformatics algorithms to determine correlations between biological information. A common problem is that similarity can appear by chance, particularly for low expressed entities. This...