Nicolas Leveille
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Explore the profile of Nicolas Leveille including associated specialties, affiliations and a list of published articles.
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17
Citations
963
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Recent Articles
1.
Schwarzmueller L, Adam R, Moreno L, Nijman L, Logiantara A, Eleonora S, et al.
Gut
. 2024 Nov;
74(4):571-585.
PMID: 39562049
Background: Aberrant Wnt pathway activation is a key driver of colorectal cancer (CRC) and is essential to sustain tumour growth and progression. Although the downstream protein-coding target genes of the...
2.
Bril O, Schwarzmueller L, Moreno L, Vermeulen L, Leveille N
STAR Protoc
. 2023 Sep;
4(4):102588.
PMID: 37773752
Long non-coding RNAs (lncRNAs) are emerging as key regulators in the initiation, growth, and progression of cancer. High-throughput CRISPR-based techniques systematically assess the function of genes or regulatory elements present...
3.
van Neerven S, Smit W, van Driel M, Kakkar V, de Groot N, Nijman L, et al.
EMBO Mol Med
. 2022 Nov;
14(12):e16194.
PMID: 36321561
The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation,...
4.
van Neerven S, de Groot N, Nijman L, Scicluna B, van Driel M, Lecca M, et al.
Nature
. 2021 Jun;
594(7863):436-441.
PMID: 34079128
A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the...
5.
Schwarzmueller L, Bril O, Vermeulen L, Leveille N
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33352769
Maintenance of the intestinal epithelium is dependent on the control of stem cell (SC) proliferation and differentiation. The fine regulation of these cellular processes requires a complex dynamic interplay between...
6.
Adam R, van Neerven S, Pleguezuelos-Manzano C, Simmini S, Leveille N, de Groot N, et al.
Cancer Cell Int
. 2020 Dec;
20(1):578.
PMID: 33292279
Background: Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early...
7.
Leveille N, Baglio S
Crit Rev Oncol Hematol
. 2019 Mar;
139:125-127.
PMID: 30890387
Exosome-mediated transfer of regulatory RNAs is a key feature that enables cancer cells to shape a tumor-promoting environment. Cancers growing in the bone can use this communication modality to disrupt...
8.
Lenos K, Miedema D, Lodestijn S, Nijman L, van den Bosch T, Ros X, et al.
Nat Cell Biol
. 2018 Sep;
20(10):1193-1202.
PMID: 30177776
Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses of lineage tracing data from primary...
9.
Baglio S, Lagerweij T, Perez-Lanzon M, Ho X, Leveille N, Melo S, et al.
Clin Cancer Res
. 2017 Jan;
23(14):3721-3733.
PMID: 28053020
Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interactions between...
10.
Leveille N, Vermeulen L
Stem Cell Investig
. 2016 Aug;
3:22.
PMID: 27488310
Intestinal stem cells (ISCs) are adult multipotent cells essential for the maintenance of intestinal epithelial homeostasis. Wnt signaling activity ensures that the pool of ISCs at the basis of the...