Nicolas J Lehrbach
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Explore the profile of Nicolas J Lehrbach including associated specialties, affiliations and a list of published articles.
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22
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1576
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Recent Articles
1.
Jochim B, Topalidou I, Lehrbach N
bioRxiv
. 2025 Feb;
PMID: 39975340
The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregulation of proteasome subunit genes and is essential for...
2.
Garcia-Toscano L, Currey H, Hincks J, Stair J, Lehrbach N, Liachko N
PLoS Genet
. 2024 Dec;
20(12):e1011518.
PMID: 39724103
Neuronal inclusions of hyperphosphorylated TDP-43 are hallmarks of disease for most patients with amyotrophic lateral sclerosis (ALS). Mutations in TARDBP, the gene coding for TDP-43, can cause some cases of...
3.
Castillo-Quan J, Steinbaugh M, Fernandez-Cardenas L, Pohl N, Wu Z, Zhu F, et al.
Sci Adv
. 2023 Jan;
9(1):eadc8917.
PMID: 36598980
Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA), promotes health and longevity. Here, we...
4.
Charlesworth A, Seroussi U, Lehrbach N, Renaud M, Sundby A, Molnar R, et al.
Nucleic Acids Res
. 2021 Jul;
49(15):8836-8865.
PMID: 34329465
The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one Argonaute is essential under normal laboratory conditions: CSR-1....
5.
Lehrbach N, Breen P, Ruvkun G
Cell
. 2019 Apr;
177(3):737-750.e15.
PMID: 31002798
The proteasome mediates selective protein degradation and is dynamically regulated in response to proteotoxic challenges. SKN-1A/Nrf1, an endoplasmic reticulum (ER)-associated transcription factor that undergoes N-linked glycosylation, serves as a sensor...
6.
Lehrbach N, Ruvkun G
Elife
. 2019 Apr;
8.
PMID: 30973820
Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed that the ER-associated SKN-1A/Nrf1 transcription factor activates proteasome...
7.
Tillman E, Richardson C, Cattie D, Reddy K, Lehrbach N, Droste R, et al.
Genetics
. 2018 Oct;
210(4):1329-1337.
PMID: 30287474
Animals have evolved critical mechanisms to maintain cellular and organismal proteostasis during development, disease, and exposure to environmental stressors. The Unfolded Protein Response (UPR) is a conserved pathway that senses...
8.
Lehrbach N, Ji F, Sadreyev R
Curr Protoc Mol Biol
. 2017 Jan;
117:7.29.1-7.29.12.
PMID: 28060408
Forward genetic analysis using chemical mutagenesis in model organisms is a powerful tool for investigation of molecular mechanisms in biological systems. In the nematode, Caenorhabditis elegans, mutagenesis screens using ethyl...
9.
Lehrbach N, Ruvkun G
Elife
. 2016 Aug;
5.
PMID: 27528192
Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in response to proteasome dysfunction caused by pathogen attacks or proteasome...
10.
Sapetschnig A, Sarkies P, Lehrbach N, Miska E
PLoS Genet
. 2015 Mar;
11(3):e1005078.
PMID: 25811365
In the nematode Caenorhabditis elegans, different small RNA-dependent gene silencing mechanisms act in the germline to initiate transgenerational gene silencing. Piwi-interacting RNAs (piRNAs) can initiate transposon and gene silencing by...