Nicolas G Simonet
Overview
Explore the profile of Nicolas G Simonet including associated specialties, affiliations and a list of published articles.
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8
Citations
293
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Recent Articles
1.
Martinez-Gutierrez A, Fernandez-Duran I, Marazuela-Duque A, Simonet N, Yousef I, Martinez-Rovira I, et al.
Aging (Albany NY)
. 2021 Apr;
13(9):12308-12333.
PMID: 33901008
UV radiation is one of the main contributors to skin photoaging by promoting the accumulation of cellular senescence, which in turn induces a proinflammatory and tissue-degrading state that favors skin...
2.
Ianni A, Kumari P, Tarighi S, Simonet N, Popescu D, Guenther S, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(5).
PMID: 33495326
Adaptation to different forms of environmental stress is crucial for maintaining essential cellular functions and survival. The nucleolus plays a decisive role as a signaling hub for coordinating cellular responses...
3.
Simonet N, Thackray J, Vazquez B, Ianni A, Espinosa-Alcantud M, Morales-Sanfrutos J, et al.
Sci Adv
. 2020 Aug;
6(30):eaaz2590.
PMID: 32832656
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity. We report that the deacetylase SirT7 is...
4.
Vazquez B, Thackray J, Simonet N, Chahar S, Kane-Goldsmith N, Newkirk S, et al.
Nucleic Acids Res
. 2019 Jun;
47(15):7870-7885.
PMID: 31226208
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process...
5.
Fang J, Ianni A, Smolka C, Vakhrusheva O, Nolte H, Kruger M, et al.
Proc Natl Acad Sci U S A
. 2017 Sep;
114(40):E8352-E8361.
PMID: 28923965
Sirtuins (Sirt1-Sirt7) are NAD-dependent protein deacetylases/ADP ribosyltransferases, which play decisive roles in chromatin silencing, cell cycle regulation, cellular differentiation, and metabolism. Different sirtuins control similar cellular processes, suggesting a coordinated...
6.
Simonet N, Vaquero A
Proteomics
. 2017 Jun;
17(13-14).
PMID: 28613014
Sirtuins are crucial proteins involved in sensing and coordinating the response to different forms of stress, mainly through NAD -dependent deacetylation of proteins. For that reason, sirtuins are directly involved...
7.
Nardocci G, Simonet N, Navarro C, Langst G, Alvarez M
Biochem Cell Biol
. 2016 Jul;
94(4):315-21.
PMID: 27458840
To ensure homeostasis, ectothermic organisms adapt to environmental variations through molecular mechanisms. We previously reported that during the seasonal acclimatization of the common carp Cyprinus carpio, molecular and cellular functions...
8.
Vazquez B, Thackray J, Simonet N, Kane-Goldsmith N, Martinez-Redondo P, Nguyen T, et al.
EMBO J
. 2016 May;
35(14):1488-503.
PMID: 27225932
Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating communication between cells and environment. The enzymatic activity of the mammalian sirtuin SIRT7 targets acetylated lysine in the N-terminal...