Nickie C Chan
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Explore the profile of Nickie C Chan including associated specialties, affiliations and a list of published articles.
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10
Citations
796
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Recent Articles
1.
Chan N, den Besten W, Sweredoski M, Hess S, Deshaies R, Chan D
J Biol Chem
. 2014 May;
289(28):19789-98.
PMID: 24855649
Because the deubiquitinating enzyme USP33 is involved in several important cellular processes (β-adrenergic receptor recycling, centrosome amplification, RalB signaling, and cancer cell migration), its levels must be carefully regulated. Using...
2.
Zhang Y, Chan N, Ngo H, Gristick H, Chan D
J Biol Chem
. 2012 Feb;
287(13):9855-9861.
PMID: 22303011
The mitochondrial fission machinery is best understood in the yeast Saccharomyces cerevisiae, where Fis1, Mdv1, and Dnm1 are essential components. Fis1 is a mitochondrial outer membrane protein that recruits the...
3.
Chan N, Chan D
Autophagy
. 2011 Apr;
7(7):771-2.
PMID: 21460629
Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous studies have established its role in mitophagy, a pathway whereby dysfunctional mitochondria are targeted for...
4.
Chan N, Salazar A, Pham A, Sweredoski M, Kolawa N, Graham R, et al.
Hum Mol Genet
. 2011 Feb;
20(9):1726-37.
PMID: 21296869
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates...
5.
Waller R, Jabbour C, Chan N, Celik N, Likic V, Mulhern T, et al.
Eukaryot Cell
. 2008 Nov;
8(1):19-26.
PMID: 19028997
Microsporidia are a group of highly adapted obligate intracellular parasites that are now recognized as close relatives of fungi. Their adaptation to parasitism has resulted in broad and severe reduction...
6.
Hulett J, Lueder F, Chan N, Perry A, Wolynec P, Likic V, et al.
J Mol Biol
. 2008 Jan;
376(3):694-704.
PMID: 18187149
Mitochondria cannot be made de novo. Mitochondrial biogenesis requires that up to 1000 proteins are imported into mitochondria, and the protein import pathway relies on hetero-oligomeric translocase complexes in both...
7.
Chan N, Lithgow T
Mol Biol Cell
. 2007 Nov;
19(1):126-36.
PMID: 17978093
The sorting and assembly machinery (SAM) complex functions in the assembly of beta-barrel proteins into the mitochondrial outer membrane. It is related to the Omp85/YaeT machinery in bacterial outer membranes,...
8.
Pal B, Chan N, Helfenbaum L, Tan K, Tansey W, Gething M
Mol Biol Cell
. 2006 Nov;
18(2):426-40.
PMID: 17108329
The Saccharomyces cerevisiae basic leucine zipper transcription factor Hac1p is synthesized in response to the accumulation of unfolded polypeptides in the lumen of the endoplasmic reticulum (ER), and it is...
9.
Burri L, Vascotto K, Gentle I, Chan N, Beilharz T, Stapleton D, et al.
FEBS J
. 2006 May;
273(7):1507-15.
PMID: 16689936
Mitochondria evolved from a bacterial endosymbiont ancestor in which the integral outer membrane proteins would have been beta-barrel structured within the plane of the membrane. Initial proteomics on the outer...
10.
Chan N, Likic V, Waller R, Mulhern T, Lithgow T
J Mol Biol
. 2006 Mar;
358(4):1010-22.
PMID: 16566938
In fungi and animals the translocase in the outer mitochondrial membrane (TOM complex) consists of multiple components including the receptor subunit Tom70. Genome sequence analyses suggest no Tom70 receptor subunit...