Nick D Read
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Explore the profile of Nick D Read including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Gago S, Overton N, Ben-Ghazzi N, Novak-Frazer L, Read N, Denning D, et al.
Nat Commun
. 2018 Sep;
9(1):3835.
PMID: 30237437
Aspergillus fumigatus is a critical pathogen of humans. Exposure to A. fumigatus conidia occurs frequently but is normally cleared from the respiratory airways. In contrast, individuals with respiratory diseases are...
12.
Development of an adaptable headspace sampling method for metabolic profiling of the fungal volatome
Ahmed W, Geranios P, White I, Lawal O, Nijsen T, Bromley M, et al.
Analyst
. 2018 Aug;
143(17):4155-4162.
PMID: 30069568
Pulmonary aspergillosis can cause serious complications in people with a suppressed immune system. Volatile metabolites emitted by Aspergillus spp. have shown promise for early detection of pathogenicity. However, volatile profiles...
13.
du Pre S, Beckmann N, Almeida M, Sibley G, Law D, Brand A, et al.
Antimicrob Agents Chemother
. 2018 Jun;
62(8).
PMID: 29891595
F901318 (olorofim) is a novel antifungal drug that is highly active against species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the...
14.
Live-cell imaging of conidial anastomosis tube fusion during colony initiation in Fusarium oxysporum
Kurian S, Di Pietro A, Read N
PLoS One
. 2018 May;
13(5):e0195634.
PMID: 29734342
Fusarium oxysporum exhibits conidial anastomosis tube (CAT) fusion during colony initiation to form networks of conidial germlings. Here we determined the optimal culture conditions for this fungus to undergo CAT...
15.
Serrano A, Illgen J, Brandt U, Thieme N, Letz A, Lichius A, et al.
J Cell Sci
. 2018 Mar;
131(9).
PMID: 29592970
Mitogen-activated protein kinases (MAPKs) are conserved regulators of proliferation, differentiation and adaptation in eukaryotic cells. Their activity often involves changes in their subcellular localization, indicating an important role for these...
16.
Loss O, Bertuzzi M, Yan Y, Fedorova N, McCann B, Armstrong-James D, et al.
Mol Microbiol
. 2017 Sep;
106(6):861-875.
PMID: 28922497
Functional coupling of calcium- and alkaline responsive signalling occurs in multiple fungi to afford efficient cation homeostasis. Host microenvironments exert alkaline stress and potentially toxic concentrations of Ca , such...
17.
Moreno-Velasquez S, Seidel C, Juvvadi P, Steinbach W, Read N
Antimicrob Agents Chemother
. 2017 Aug;
61(10).
PMID: 28760907
Caspofungin targets cell wall β-1,3-glucan synthesis and is the international consensus guideline-recommended salvage therapy for invasive aspergillosis. Although caspofungin is inhibitory at low concentrations, it exhibits a paradoxical effect (reversal...
18.
Mendive-Tapia L, Subiros-Funosas R, Zhao C, Albericio F, Read N, Lavilla R, et al.
Nat Protoc
. 2017 Jul;
12(8):1588-1619.
PMID: 28703788
Fluorescent peptides are valuable tools for live-cell imaging because of the high specificity of peptide sequences for their biomolecular targets. When preparing fluorescent versions of peptides, labels must be introduced...
19.
Sonderegger C, Fizil A, Burtscher L, Hajdu D, Munoz A, Gaspari Z, et al.
PLoS One
. 2017 Jan;
12(1):e0169920.
PMID: 28072824
The cysteine-rich, cationic, antifungal protein PAF is abundantly secreted into the culture supernatant of the filamentous Ascomycete Penicillium chrysogenum. The five β-strands of PAF form a compact β-barrel that is...
20.
Alshehri J, Caballero-Lima D, Hillarby M, Shawcross S, Brahma A, Carley F, et al.
Invest Ophthalmol Vis Sci
. 2016 Nov;
57(14):6367-6373.
PMID: 27898982
Purpose: Some previous reports have established the use of photoactivated chromophore-induced corneal cross-linking (PACK-CXL) in treating fungal keratitis. The results of these case reports have often been conflicting. To systematically...