Nicholas W Chavkin
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Explore the profile of Nicholas W Chavkin including associated specialties, affiliations and a list of published articles.
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27
Citations
573
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Recent Articles
1.
Evans M, Chavkin N, Sano S, Sun H, Sardana T, Ravi R, et al.
Front Cell Neurosci
. 2025 Jan;
18:1487867.
PMID: 39742155
Introduction: Recent work has revealed that clonal hematopoiesis (CH) is associated with a higher risk of numerous age-related diseases, including ischemic stroke, however little is known about whether it influences...
2.
Chavkin N, Evans M, Walsh K
Nat Cardiovasc Res
. 2024 Aug;
2(9):801-802.
PMID: 39196066
No abstract available.
3.
Horitani K, Chavkin N, Arai Y, Wang Y, Ogawa H, Yura Y, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(3):343-355.
PMID: 39183958
Heart failure affects millions of people worldwide, with men exhibiting a higher incidence than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in leukocytes...
4.
Thel M, Cochran J, Teruya S, Hayashi O, Xie C, Srinivasan A, et al.
Circ Heart Fail
. 2024 Jun;
17(8):e011681.
PMID: 38853760
No abstract available.
5.
Genet G, Genet N, Paila U, Cain S, Cwiek A, Chavkin N, et al.
Circulation
. 2023 Dec;
149(12):944-962.
PMID: 38126211
Background: Distinct endothelial cell cycle states (early G1 versus late G1) provide different "windows of opportunity" to enable the differential expression of genes that regulate venous versus arterial specification, respectively....
6.
Dunaway L, Luse M, Nyshadham S, Bulut G, Alencar G, Chavkin N, et al.
Physiol Genomics
. 2023 Nov;
56(2):113-127.
PMID: 37982169
Endothelial cells (ECs) adapt to the unique needs of their resident tissue and metabolic perturbations, such as obesity. We sought to understand how obesity affects EC metabolic phenotypes, specifically mitochondrial...
7.
Chavkin N, Vippa T, Jung C, McDonnell S, Hirschi K, Gokce N, et al.
Front Cardiovasc Med
. 2023 Oct;
10:1264479.
PMID: 37795485
Introduction: Vascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an endothelial-to-mesenchymal transition (EndoMT), where endothelial cells undergo a phenotypic switch to mesenchymal-like...
8.
Cochran J, Yura Y, Thel M, Doviak H, Polizio A, Arai Y, et al.
Circulation
. 2023 Sep;
148(15):1165-1178.
PMID: 37681311
Background: Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse...
9.
Acharya B, Fang J, Jeffery E, Chavkin N, Genet G, Vasavada H, et al.
Life Sci Alliance
. 2023 May;
6(8).
PMID: 37197981
Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest lack mechanistic understanding. We previously showed that arterial shear stress up-regulates Cx37 in endothelial cells and activates a Notch/Cx37/p27 signaling...
10.
Genet N, Genet G, Chavkin N, Paila U, Fang J, Vasavada H, et al.
Cell Rep
. 2023 Apr;
42(4):112371.
PMID: 37043357
The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSCs and endothelial cells...