Nicholas Treen
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Explore the profile of Nicholas Treen including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
164
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Recent Articles
1.
Liu D, Lum K, Treen N, Nunez C, Yang J, Howard T, et al.
Nucleic Acids Res
. 2023 Jun;
51(13):6819-6840.
PMID: 37283074
The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA, initiating innate immune signaling and suppressing viral transcription. However, little is known about mechanisms that initiate...
2.
Treen N, Konishi S, Nishida H, Onuma T, Sasakura Y
Dev Biol
. 2023 Mar;
498:26-34.
PMID: 36965841
The control of cell numbers and the establishment of cell types are two processes that are essential in early embryonic development. We have a reasonable understanding of how these processes...
3.
Treen N, Chavarria E, Weaver C, Brangwynne C, Levine M
Genes Dev
. 2023 Feb;
37(3-4):80-85.
PMID: 36801820
Zygotic genome activation has been extensively studied in a variety of systems including flies, frogs, and mammals. However, there is comparatively little known about the precise timing of gene induction...
4.
Weaver C, Patel A, Shvartsman S, Levine M, Treen N
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35217620
Phase separation underlies the organization of the nucleus, including the biogenesis of nucleoli and the packaging of heterochromatin. Here we explore the regulation of transcription factor condensates involved in gene...
5.
Treen N, Shimobayashi S, Eeftens J, Brangwynne C, Levine M
Nat Commun
. 2021 Mar;
12(1):1561.
PMID: 33692345
Recent studies suggest that transcriptional activators and components of the pre-initiation complex (PIC) form higher order associations-clusters or condensates-at active loci. Considerably less is known about the distribution of repressor...
6.
Hozumi A, Matsunobu S, Mita K, Treen N, Sugihara T, Horie T, et al.
Curr Biol
. 2020 Mar;
30(8):1555-1561.e4.
PMID: 32220316
Metamorphosis, a widespread life history strategy in metazoans, allows dispersal and use of different ecological niches through a dramatic body change from a larval stage [1, 2]. Despite its conservation...
7.
Tajima Y, Hozumi A, Yoshida K, Treen N, Sakuma T, Yamamoto T, et al.
Dev Biol
. 2019 Nov;
458(1):120-131.
PMID: 31682808
Species-specific traits are thought to have been acquired by natural selection. Transcription factors play central roles in the evolution of species-specific traits. Hox genes encode a set of conserved transcription...
8.
Treen N, Heist T, Wang W, Levine M
Curr Biol
. 2018 Apr;
28(8):1330-1331.
PMID: 29689201
No abstract available.
9.
Treen N, Heist T, Wang W, Levine M
Curr Biol
. 2018 Mar;
28(7):1150-1156.e4.
PMID: 29576477
Most animal embryos display a delay in the activation of zygotic transcription during early embryogenesis [1]. This process is thought to help coordinate rapid increases in cell number during early...
10.
Yoshida K, Treen N
Adv Exp Med Biol
. 2018 Mar;
1029:131-139.
PMID: 29542086
Targeted mutagenesis of genes-of-interest is a powerful method of addressing the functions of genes. Genome editing techniques, such as transcriptional activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic...