Nicholas Stoy
Overview
Explore the profile of Nicholas Stoy including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
428
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Recent Articles
1.
Stoy N
Front Immunol
. 2021 May;
12:638446.
PMID: 33936053
Interleukin-1 receptor-associated kinase 4 (IRAK4) and interferon regulatory factor 5 (IRF5) lie sequentially on a signaling pathway activated by ligands of the IL-1 receptor and/or multiple TLRs located either on...
2.
Wu H, von Kamp A, Leoncikas V, Mori W, Sahin N, Gevorgyan A, et al.
NPJ Syst Biol Appl
. 2017 Jul;
2:16032.
PMID: 28725480
Systems Biology has established numerous approaches for mechanistic modeling of molecular networks in the cell and a legacy of models. The current frontier is the integration of models expressed in...
3.
McCourt A, ODonovan K, Ekblad E, Sand E, Craufurd D, Rosser A, et al.
PLoS Curr
. 2015 Nov;
7.
PMID: 26581667
Weight loss is an important complication of Huntington's disease (HD), however the mechanism for weight loss in HD is not entirely understood. Mutant huntingtin is expressed in the gastrointestinal (GI)...
4.
Stone T, Stoy N, Darlington L
Trends Pharmacol Sci
. 2012 Nov;
34(2):136-43.
PMID: 23123095
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems. Kynurenine...
5.
Darlington L, Forrest C, Mackay G, Smith R, Smith A, Stoy N, et al.
Int J Tryptophan Res
. 2011 Nov;
3:51-9.
PMID: 22084587
Of the major components of the kynurenine pathway for the oxidative metabolism of tryptophan, most attention has focussed on the N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid, and the glutamate receptor...
6.
Stone T, Forrest C, Stoy N, Darlington L
J Neural Transm (Vienna)
. 2011 Jun;
119(2):261-74.
PMID: 21695417
Several components of the kynurenine pathway of tryptophan metabolism are now recognised to have actions of profound biological importance. These include the ability to modulate the activation of glutamate and...
7.
Spring J, Baker M, Dauya L, Ewemade I, Marsh N, Patel P, et al.
Disabil Rehabil
. 2010 May;
33(2):159-64.
PMID: 20491614
Purpose: A programme of garden-related indoor activities was developed to sustain a gardening group for people with mid to late stage Huntington's disease during the winter. Method: The activities were...
8.
Forrest C, Mackay G, Stoy N, Spiden S, Taylor R, Stone T, et al.
J Neurochem
. 2009 Oct;
112(1):112-22.
PMID: 19845828
There is substantial evidence that abnormal concentrations of oxidised tryptophan metabolites, produced via the kynurenine pathway, contribute to progressive neurodegeneration in Huntington's disease. We have now examined the blood levels...
9.
Forrest C, Mackay G, Stoy N, Stone T, Darlington L
Br J Clin Pharmacol
. 2007 May;
64(4):517-26.
PMID: 17506781
Aim: Since melatonin is antioxidant and has some anti-inflammatory actions, we have tested it as adjunctive treatment in patients with rheumatoid arthritis, to determine whether it can improve patients' symptoms....
10.
Forrest C, Mackay G, Oxford L, Stoy N, Stone T, Darlington L
Clin Exp Pharmacol Physiol
. 2006 Oct;
33(11):1078-87.
PMID: 17042918
1. Metabolism of tryptophan along the oxidative pathway via kynurenine results in the production of quinolinic acid and kynurenic acid, which can act on glutamate receptors in peripheral tissues. We...