Nicholas Stavropoulos
Overview
Explore the profile of Nicholas Stavropoulos including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
325
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Recent Articles
1.
Li Q, Lim K, Altawell R, Verderose F, Li X, Dong W, et al.
PLoS Genet
. 2025 Jan;
21(1):e1011574.
PMID: 39841692
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins...
2.
Tener S, Lin Z, Park S, Oraedu K, Ulgherait M, Van Beek E, et al.
Sci Rep
. 2024 Jan;
14(1):1541.
PMID: 38233464
Mutations in Cullin-3 (Cul3), a conserved gene encoding a ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we characterize ASD-related pathologies caused by neuron-specific Cul3 knockdown in...
3.
Li Q, Jang H, Lim K, Lessing A, Stavropoulos N
Elife
. 2021 Dec;
10.
PMID: 34908527
Although many genes are known to influence sleep, when and how they impact sleep-regulatory circuits remain ill-defined. Here, we show that (), a conserved adaptor for the autism-associated Cul3 ubiquitin...
4.
Kikuma K, Li X, Perry S, Li Q, Goel P, Chen C, et al.
Nat Commun
. 2019 Jul;
10(1):2998.
PMID: 31278365
At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors activates retrograde signaling that precisely increases presynaptic neurotransmitter release to restore baseline synaptic strength. However, the nature of the underlying...
5.
Alvarez-Salvado E, Licata A, Connor E, McHugh M, King B, Stavropoulos N, et al.
Elife
. 2018 Aug;
7.
PMID: 30129438
Odor attraction in walking is commonly used to relate neural function to behavior, but the algorithms underlying attraction are unclear. Here, we develop a high-throughput assay to measure olfactory behavior...
6.
Hill V, OConnor R, Sissoko G, Irobunda I, Leong S, Canman J, et al.
PLoS Biol
. 2018 Jul;
16(7):e2005206.
PMID: 30001323
Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse...
7.
Li Q, Kellner D, Hatch H, Yumita T, Sanchez S, Machold R, et al.
PLoS Genet
. 2017 May;
13(5):e1006815.
PMID: 28558011
Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the...
8.
Li Q, Stavropoulos N
G3 (Bethesda)
. 2016 Aug;
6(10):3351-3359.
PMID: 27558667
Drosophila melanogaster is a powerful model organism for dissecting the molecular mechanisms that regulate sleep, and numerous studies in the fly have identified genes that impact sleep-wake cycles. Conditional genetic...
9.
Stavropoulos N, Young M
Neuron
. 2011 Dec;
72(6):964-76.
PMID: 22196332
In a forward genetic screen in Drosophila, we have isolated insomniac, a mutant that severely reduces the duration and consolidation of sleep. Anatomically restricted genetic manipulations indicate that insomniac functions...
10.
Stavropoulos N, Rowntree R, Lee J
Mol Cell Biol
. 2005 Mar;
25(7):2757-69.
PMID: 15767680
X chromosome inactivation silences one of two X chromosomes in the mammalian female cell and is controlled by a binary switch that involves interactions between Xist and Tsix, a sense-antisense...