Nicholas Regan
Overview
Explore the profile of Nicholas Regan including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
122
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Recent Articles
1.
Walters Haygood C, Arend R, Gangrade A, Chettiar S, Regan N, Hassmann 2nd C, et al.
Int J Gynecol Cancer
. 2015 Jul;
25(8):1377-85.
PMID: 26186072
Objective: Niclosamide has shown activity against ovarian cancer in vitro; however, it has low bioavailability in vivo. Therefore, we investigated the cytotoxicity of niclosamide analogs in combination with carboplatin against...
2.
Wickham S, Regan N, West M, Thai J, Cook P, Terzyan S, et al.
Biochem J
. 2013 Jan;
450(3):547-57.
PMID: 23301618
GGT (γ-glutamyl transpeptidase) is an essential enzyme for maintaining cysteine homoeostasis, leukotriene synthesis, metabolism of glutathione conjugates and catabolism of extracellular glutathione. Overexpression of GGT has been implicated in many...
3.
Wickham S, Regan N, West M, Kumar V, Thai J, Li P, et al.
J Enzyme Inhib Med Chem
. 2011 Aug;
27(4):476-89.
PMID: 21864033
A novel class of inhibitors of the enzyme γ-glutamyl transpeptidase (GGT) were evaluated. The analog OU749 was shown previously to be an uncompetitive inhibitor of the GGT transpeptidation reaction. The...
4.
Wu X, Wang L, Han Y, Regan N, Li P, Villalona M, et al.
ACS Comb Sci
. 2011 Jul;
13(5):486-95.
PMID: 21766878
FK506 and rapamycin are immunosuppressive drugs with a unique mode of action. Prior to binding to their protein targets, these drugs form a complex with an endogenous chaperone FK506-binding protein...
5.
Fuchs J, Pandit B, Bhasin D, Etter J, Regan N, Abdelhamid D, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(7):2065-9.
PMID: 19249204
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast...
6.
Bhasin D, Cisek K, Pandharkar T, Regan N, Li C, Pandit B, et al.
Bioorg Med Chem Lett
. 2007 Nov;
18(1):391-5.
PMID: 18006313
A series of small molecule STAT3 inhibitors originally derived from our lead compound STA 21 were synthesized and evaluated. The most potent compound in this series, compound 1, exhibited the...