Nicholas P Marotta
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Explore the profile of Nicholas P Marotta including associated specialties, affiliations and a list of published articles.
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11
Citations
356
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Recent Articles
1.
Venkatesh Y, Marotta N, Lee V, Petersson E
Chem Sci
. 2024 Apr;
15(16):6053-6063.
PMID: 38665526
Small molecule fluorescent probes are indispensable tools for a broad range of biological applications. Despite many probes being available, there is still a need for probes where photophysical properties and...
2.
Uemura N, Marotta N, Ara J, Meymand E, Zhang B, Kameda H, et al.
Nat Commun
. 2023 Oct;
14(1):6892.
PMID: 37898614
Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We...
3.
Marotta N, Lee V
Curr Opin Neurobiol
. 2022 Feb;
72:171-177.
PMID: 35131527
Parkinson's disease is a progressive neurodegenerative disorder that is characterized by pathological protein inclusions that form in the brains of patients, leading to neuron loss and the observed clinical symptoms....
4.
Marotta N, Ara J, Uemura N, Lougee M, Meymand E, Zhang B, et al.
Acta Neuropathol Commun
. 2021 Nov;
9(1):188.
PMID: 34819159
Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to...
5.
Chuh K, Batt A, Zaro B, Darabedian N, Marotta N, Brennan C, et al.
J Am Chem Soc
. 2017 May;
139(23):7872-7885.
PMID: 28528544
O-GlcNAc modification (O-GlcNAcylation) is required for survival in mammalian cells. Genetic and biochemical experiments have found that increased modification inhibits apoptosis in tissues and cell culture and that lowering O-GlcNAcylation...
6.
Levine P, De Leon C, Galesic A, Balana A, Marotta N, Lewis Y, et al.
Bioorg Med Chem
. 2017 May;
25(18):4977-4982.
PMID: 28487126
The major protein associated with Parkinson's disease (PD) is α-synuclein, as it can form toxic amyloid-aggregates that are a hallmark of many neurodegenerative diseases. α-Synuclein is a substrate for several...
7.
Marotta N, Lin Y, Lewis Y, Ambroso M, Zaro B, Roth M, et al.
Nat Chem
. 2015 Oct;
7(11):913-20.
PMID: 26492012
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies, including...
8.
Pratt M, Abeywardana T, Marotta N
Biomolecules
. 2015 Jun;
5(3):1210-27.
PMID: 26120904
α-Synuclein is the aggregation-prone protein associated with Parkinson's disease (PD) and related neurodegenerative diseases. Complicating both its biological functions and toxic aggregation are a variety of posttranslational modifications. These modifications...
9.
Marotta N, Cherwien C, Abeywardana T, Pratt M
Chembiochem
. 2012 Nov;
13(18):2665-70.
PMID: 23143740
Sweet relief: the Parkinson's disease- associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate...
10.
Meier F, Abeywardana T, Dhall A, Marotta N, Varkey J, Langen R, et al.
J Am Chem Soc
. 2012 Mar;
134(12):5468-71.
PMID: 22404520
The process of neurodegeneration in Parkinson's Disease is intimately associated with the aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of these protein aggregates are found...