Nicholas N Smithers
Overview
Explore the profile of Nicholas N Smithers including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
3
Citations
219
Followers
0
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Recent Articles
1.
Elfiky A, Hageman I, Becker M, Verhoeff J, Li Yim A, Joustra V, et al.
Cells
. 2022 Sep;
11(18).
PMID: 36139421
Background: Myeloid cells are critical determinants of the sustained inflammation in Crohn's Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal...
2.
Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry M, et al.
Blood
. 2013 Dec;
123(5):697-705.
PMID: 24335499
The bromodomain and extraterminal (BET) protein BRD2-4 inhibitors hold therapeutic promise in preclinical models of hematologic malignancies. However, translation of these data to molecules suitable for clinical development has yet...
3.
Mirguet O, Gosmini R, Toum J, Clement C, Barnathan M, Brusq J, et al.
J Med Chem
. 2013 Sep;
56(19):7501-15.
PMID: 24015967
The bromo and extra C-terminal domain (BET) family of bromodomains are involved in binding epigenetic marks on histone proteins, more specifically acetylated lysine residues. This paper describes the discovery and...