Andrea C Haynes
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Explore the profile of Andrea C Haynes including associated specialties, affiliations and a list of published articles.
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7
Citations
321
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Recent Articles
1.
Gobbetti T, Berger S, Fountain K, Slocombe T, Rowles A, Pearse G, et al.
Cell Death Dis
. 2020 Apr;
11(4):220.
PMID: 32249785
No abstract available.
2.
Huang W, Haynes A, Mukherjee R, Wen L, Latawiec D, Tepikin A, et al.
Pancreatology
. 2017 Jun;
17(5):689-697.
PMID: 28648518
Objectives: To evaluate the therapeutic potential of I-BET-762, an inhibitor of the bromodomain and extra-terminal (BET) protein family, in experimental acute pancreatitis (AP). Methods: AP was induced by retrograde infusion...
3.
Huang W, Cane M, Mukherjee R, Szatmary P, Zhang X, Elliott V, et al.
Gut
. 2015 Dec;
66(2):301-313.
PMID: 26642860
Objective: Caffeine reduces toxic Ca signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IPR)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of...
4.
Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry M, et al.
Blood
. 2013 Dec;
123(5):697-705.
PMID: 24335499
The bromodomain and extraterminal (BET) protein BRD2-4 inhibitors hold therapeutic promise in preclinical models of hematologic malignancies. However, translation of these data to molecules suitable for clinical development has yet...
5.
Mirguet O, Gosmini R, Toum J, Clement C, Barnathan M, Brusq J, et al.
J Med Chem
. 2013 Sep;
56(19):7501-15.
PMID: 24015967
The bromo and extra C-terminal domain (BET) family of bromodomains are involved in binding epigenetic marks on histone proteins, more specifically acetylated lysine residues. This paper describes the discovery and...
6.
Smart D, Haynes A, Williams G, Arch J
Eur J Pharmacol
. 2002 May;
440(2-3):199-212.
PMID: 12007536
Orexin-A and -B are two peptides derived by proteolytic cleavage from a 130-amino acid precursor, prepro-orexin, which were recently isolated from the rat hypothalamus. Orexin-A is fully conserved across mammalian...
7.
Haynes A, Chapman H, Taylor C, Moore G, Cawthorne M, Tadayyon M, et al.
Regul Pept
. 2002 Feb;
104(1-3):153-9.
PMID: 11830290
A single dose of the orexin-1 (OX1) receptor antagonist 1-(2-methylbenzoxazol-6-yl)-3-[1,5] naphthyridin-4-yl urea hydrochloride (SB-334867-A) reduces orexin-A-induced feeding and natural feeding in Sprague Dawley rats. In this study, the anti-obesity effects...