Nicholas Matthews
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Explore the profile of Nicholas Matthews including associated specialties, affiliations and a list of published articles.
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9
Citations
9293
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Recent Articles
1.
Huskey R, Bowman N, Eden A, Grizzard M, Hahn L, Lewis R, et al.
Nat Hum Behav
. 2019 Apr;
2(5):315.
PMID: 30962604
No abstract available.
2.
Khalique S, Naidoo K, Attygalle A, Kriplani D, Daley F, Lowe A, et al.
J Pathol Clin Res
. 2018 Apr;
4(3):154-166.
PMID: 29659191
ARID1A is a tumour suppressor gene that is frequently mutated in clear cell and endometrioid carcinomas of the ovary and endometrium and is an important clinical biomarker for novel treatment...
3.
Lopez-Garcia C, Sansregret L, Domingo E, McGranahan N, Hobor S, Birkbak N, et al.
Cancer Cell
. 2017 Jan;
31(1):79-93.
PMID: 28073006
Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes....
4.
Gerlinger M, Horswell S, Larkin J, Rowan A, Salm M, Varela I, et al.
Nat Genet
. 2014 Feb;
46(3):225-233.
PMID: 24487277
Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified...
5.
Howe K, Clark M, Torroja C, Torrance J, Berthelot C, Muffato M, et al.
Nature
. 2013 Apr;
496(7446):498-503.
PMID: 23594743
Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this species, and the ability to accelerate genetic studies by gene knockdown...
6.
Horswell S, Matthews N, Swanton C
Cancer Lett
. 2012 Nov;
340(2):220-6.
PMID: 23142290
The notions of inter- and intra-tumour heterogeneity (ITH) have been recognised for many years but recent advances in sequencing technology are allowing the true extent of both forms of heterogeneity...
7.
Gerlinger M, Rowan A, Horswell S, Math M, Larkin J, Endesfelder D, et al.
N Engl J Med
. 2012 Mar;
366(10):883-892.
PMID: 22397650
Background: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. Methods: To examine intratumor heterogeneity, we performed exome sequencing,...
8.
Okeke I, Wallace-Gadsden F, Simons H, Matthews N, Labar A, Hwang J, et al.
PLoS One
. 2010 Dec;
5(11):e14093.
PMID: 21124856
Background: Enteroaggregative Escherichia coli (EAEC) are defined by their stacked-brick adherence pattern to human epithelial cells. There is no all-encompassing genetic marker for EAEC. The category is commonly implicated in...
9.
Birney E, Stamatoyannopoulos J, Dutta A, Guigo R, Gingeras T, Margulies E, et al.
Nature
. 2007 Jun;
447(7146):799-816.
PMID: 17571346
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the...