Grant S Murphy
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Explore the profile of Grant S Murphy including associated specialties, affiliations and a list of published articles.
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11
Citations
329
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Recent Articles
1.
Li X, Kuchinski L, Park A, Murphy G, Soto K, Schuster B
Biotechnol Bioeng
. 2024 Jul;
121(10):3155-3168.
PMID: 38951956
In recent decades, biocatalysis has emerged as an important alternative to chemical catalysis in pharmaceutical manufacturing. Biocatalysis is attractive because enzymatic cascades can synthesize complex molecules with incredible selectivity, yield,...
2.
Cheung-Lee W, Kolev J, McIntosh J, Gil A, Pan W, Xiao L, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(13):e202316133.
PMID: 38279624
Biocatalytic oxidations are an emerging technology for selective C-H bond activation. While promising for a range of selective oxidations, practical use of enzymes catalyzing aerobic hydroxylation is presently limited by...
3.
McIntosh J, Liu Z, Andresen B, Marzijarani N, Moore J, Marshall N, et al.
Nature
. 2022 Mar;
603(7901):439-444.
PMID: 35296845
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by...
4.
McIntosh J, Benkovics T, Silverman S, Huffman M, Kong J, Maligres P, et al.
ACS Cent Sci
. 2021 Dec;
7(12):1980-1985.
PMID: 34963891
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to...
5.
Hiraga K, Mejzlik P, Marcisin M, Vostrosablin N, Gromek A, Arnold J, et al.
ACS Synth Biol
. 2021 Jan;
10(2):357-370.
PMID: 33433999
Protein engineering is the discipline of developing useful proteins for applications in research, therapeutic, and industrial processes by modification of naturally occurring proteins or by invention of proteins. Modern protein...
6.
Huffman M, Fryszkowska A, Alvizo O, Borra-Garske M, Campos K, Canada K, et al.
Science
. 2019 Dec;
366(6470):1255-1259.
PMID: 31806816
Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve chemical synthesis. Combining enzymatic reactions into multistep biocatalytic cascades brings additional benefits....
7.
Donnelly A, Murphy G, Digianantonio K, Hecht M
Nat Chem Biol
. 2018 Jan;
14(3):253-255.
PMID: 29334382
Producing novel enzymes that are catalytically active in vitro and biologically functional in vivo is a key goal of synthetic biology. Here we describe Syn-F4, the first de novo protein...
8.
Murphy G, Greisman J, Hecht M
J Mol Biol
. 2015 Dec;
428(2 Pt A):399-411.
PMID: 26707197
Designing and producing novel proteins that fold into stable structures and provide essential biological functions are key goals in synthetic biology. In initial steps toward achieving these goals, we constructed...
9.
Murphy G, Sathyamoorthy B, Der B, Machius M, Pulavarti S, Szyperski T, et al.
Protein Sci
. 2014 Oct;
24(4):434-45.
PMID: 25287625
The de novo design of proteins is a rigorous test of our understanding of the key determinants of protein structure. The helix bundle is an interesting de novo design model...
10.
Beck M, Dixon R, Goicoechea S, Murphy G, Brungardt J, Beam M, et al.
J Mol Biol
. 2013 Jun;
425(18):3325-37.
PMID: 23806659
Here, we report the NMR structure of the actin-binding domain contained in the cell adhesion protein palladin. Previously, we demonstrated that one of the immunoglobulin domains of palladin (Ig3) is...