Nicholas J Croucher
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Explore the profile of Nicholas J Croucher including associated specialties, affiliations and a list of published articles.
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104
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Recent Articles
21.
Chaguza C, Ebruke C, Senghore M, Lo S, Tientcheu P, Gladstone R, et al.
Genome Biol Evol
. 2022 Apr;
14(4).
PMID: 35439297
The isolation of Streptococcus pneumoniae serotypes in systemic tissues of patients with invasive disease versus the nasopharynx of healthy individuals with asymptomatic carriage varies widely. Some serotypes are hyper-invasive, particularly...
22.
Stevens E, Morse D, Bonini D, Duggan S, Brignoli T, Recker M, et al.
Microb Genom
. 2022 Apr;
8(4).
PMID: 35416147
is a major human pathogen that can cause severe invasive diseases such as pneumonia, septicaemia and meningitis. Young children are at a particularly high risk, with an estimated 3-4 million...
23.
Mallawaarachchi S, Tonkin-Hill G, Croucher N, Turner P, Speed D, Corander J, et al.
NAR Genom Bioinform
. 2022 Feb;
4(1):lqac011.
PMID: 35211669
Whole-genome sequencing has facilitated genome-wide analyses of association, prediction and heritability in many organisms. However, such analyses in bacteria are still in their infancy, being limited by difficulties including genome...
24.
Lochen A, Truscott J, Croucher N
PLoS Comput Biol
. 2022 Feb;
18(2):e1009389.
PMID: 35176026
The disease burden attributable to opportunistic pathogens depends on their prevalence in asymptomatic colonisation and the rate at which they progress to cause symptomatic disease. Increases in infections caused by...
25.
Chaguza C, Tonkin-Hill G, Lo S, Hadfield J, Croucher N, Harris S, et al.
Bioinformatics
. 2021 Dec;
38(5):1450-1451.
PMID: 34864895
Summary: Homologous recombination is an important evolutionary process in bacteria and other prokaryotes, which increases genomic sequence diversity and can facilitate adaptation. Several methods and tools have been developed to...
26.
Wan Y, Mills E, Leung R, Vieira A, Zhi X, Croucher N, et al.
Microb Genom
. 2021 Dec;
7(12).
PMID: 34860151
No abstract available.
27.
DAeth J, van der Linden M, McGee L, de Lencastre H, Turner P, Song J, et al.
Elife
. 2021 Jul;
10.
PMID: 34259624
Multidrug-resistant emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant lineages PMEN3...
28.
Harrow G, Lees J, Hanage W, Lipsitch M, Corander J, Colijn C, et al.
ISME J
. 2021 Jan;
15(5):1523-1538.
PMID: 33408365
Streptococcus pneumoniae can be divided into many strains, each a distinct set of isolates sharing similar core and accessory genomes, which co-circulate within the same hosts. Previous analyses suggested the...
29.
Lochen A, Croucher N, Anderson R
Sci Rep
. 2020 Nov;
10(1):18977.
PMID: 33149149
Streptococcus pneumoniae is a significant cause of otitis media, pneumonia, and meningitis. Only seven of the approximately 100 serotypes were initially included in the pneumococcal polysaccharide conjugate vaccine (PCV) in...
30.
Azarian T, Martinez P, Arnold B, Qiu X, Grant L, Corander J, et al.
PLoS Biol
. 2020 Oct;
18(10):e3000878.
PMID: 33091022
Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important human pathogen, and the pneumococcal conjugate vaccines (PCVs), which target...