Nicholas J Croucher
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Explore the profile of Nicholas J Croucher including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Belman S, Pesonen H, Croucher N, Bentley S, Corander J
G3 (Bethesda)
. 2024 Mar;
14(6).
PMID: 38507601
Streptococcus pneumoniae (the pneumococcus) is a globally distributed, human obligate opportunistic bacterial pathogen which, although often carried commensally, is also a significant cause of invasive disease. Apart from multi-drug resistant...
12.
Pontinen A, Gladstone R, Pesonen H, Pesonen M, Cleon F, Parcell B, et al.
Lancet Microbe
. 2024 Jan;
5(2):e142-e150.
PMID: 38219757
Background: The effect of antibiotic usage on the success of multidrug-resistant (MDR) clones in a population remains unclear. With this genomics-based molecular epidemiology study, we aimed to investigate the contribution...
13.
Croucher N, Campo J, Le T, Pablo J, Hung C, Teng A, et al.
Nat Commun
. 2024 Jan;
15(1):355.
PMID: 38191887
Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire recognising pneumococci from birth to 24 months old (mo) in a prospectively-sampled...
14.
Kwun M, Ion A, Oggioni M, Bentley S, Croucher N
Nucleic Acids Res
. 2023 Sep;
51(19):10375-10394.
PMID: 37757859
Despite enabling Streptococcus pneumoniae to acquire antibiotic resistance and evade vaccine-induced immunity, transformation occurs at variable rates across pneumococci. Phase variants of isolate RMV7, distinguished by altered methylation patterns driven...
15.
Horsfield S, Tonkin-Hill G, Croucher N, Lees J
Genome Res
. 2023 Aug;
33(9):1622-1637.
PMID: 37620118
Bacterial genomes differ in both gene content and sequence mutations, which underlie extensive phenotypic diversity, including variation in susceptibility to antimicrobials or vaccine-induced immunity. To identify and quantify important variants,...
16.
Glanville D, Gazioglu O, Marra M, Tokars V, Kushnir T, Habtom M, et al.
PLoS Pathog
. 2023 Jan;
19(1):e1011035.
PMID: 36719895
Streptococcus pneumoniae (the pneumococcus) is the major cause of bacterial pneumonia in the US and worldwide. Studies have shown that the differing chemical make-up between serotypes of its most important...
17.
Kwun M, Ion A, Cheng H, DAeth J, Dougan S, Oggioni M, et al.
Genome Med
. 2022 Dec;
14(1):144.
PMID: 36539881
Background: The respiratory pathogen Streptococcus pneumoniae (the pneumococcus) is a genetically diverse bacterium associated with over 101 immunologically distinct polysaccharide capsules (serotypes). Polysaccharide conjugate vaccines (PCVs) have successfully eliminated multiple...
18.
Tonkin-Hill G, Ling C, Chaguza C, Salter S, Hinfonthong P, Nikolaou E, et al.
Nat Microbiol
. 2022 Oct;
7(11):1791-1804.
PMID: 36216891
Characterizing the genetic diversity of pathogens within the host promises to greatly improve surveillance and reconstruction of transmission chains. For bacteria, it also informs our understanding of inter-strain competition and...
19.
Lehtinen S, Croucher N, Blanquart F, Fraser C
Proc Biol Sci
. 2022 Oct;
289(1984):20221197.
PMID: 36196547
Bacteriocins, toxic peptides involved in the competition between bacterial strains, are extremely diverse. Previous work on bacteriocin dynamics has highlighted the role of non-transitive 'rock-paper-scissors' competition in maintaining the coexistence...
20.
Gladstone R, McNally A, Pontinen A, Tonkin-Hill G, Lees J, Skyten K, et al.
Lancet Microbe
. 2022 May;
2(7):e331-e341.
PMID: 35544167
Background: The clonal diversity underpinning trends in multidrug resistant Escherichia coli causing bloodstream infections remains uncertain. We aimed to determine the contribution of individual clones to resistance over time, using...