Nicholas Francella
Overview
Explore the profile of Nicholas Francella including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
668
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0
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Recent Articles
1.
Elliott S, Wetzel K, Francella N, Bryan S, Romero D, Riddick N, et al.
J Virol
. 2015 Jun;
89(18):9252-61.
PMID: 26109719
Unlabelled: Natural-host sooty mangabeys (SM) infected with simian immunodeficiency virus (SIV) exhibit high viral loads but do not develop disease, whereas infection of rhesus macaques (RM) causes CD4(+) T cell...
2.
Kilgore K, Murphy M, Burton S, Wetzel K, Smith S, Xiao P, et al.
J Virol
. 2015 May;
89(16):8130-51.
PMID: 26018167
Unlabelled: Antibodies that can neutralize diverse viral strains are likely to be an important component of a protective human immunodeficiency virus type 1 (HIV-1) vaccine. To this end, preclinical simian...
3.
Francella N, Elliott S, Yi Y, Gwyn S, Ortiz A, Li B, et al.
Retrovirology
. 2013 Nov;
10:133.
PMID: 24219995
Background: HIV and SIV generally require CD4 binding prior to coreceptor engagement, but Env can acquire the ability to use CCR5 independently of CD4 under various circumstances. The ability to...
4.
Gorry P, Francella N, Lewin S, Collman R
J Leukoc Biol
. 2013 Oct;
95(1):71-81.
PMID: 24158961
Myeloid cells residing in the CNS and lymphoid tissues are targets for productive HIV-1 replication, and their infection contributes to the pathological manifestations of HIV-1 infection. The Envs can adopt...
5.
Francella N, Gwyn S, Yi Y, Li B, Xiao P, Elliott S, et al.
J Virol
. 2013 Jul;
87(17):9719-32.
PMID: 23824793
CD4(+) T cells rather than macrophages are the principal cells infected by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) in vivo. Macrophage tropism has been linked...
6.
Onder O, Humphrey P, McOmber B, Korobova F, Francella N, Greenbaum D, et al.
J Biol Chem
. 2012 Mar;
287(20):16860-8.
PMID: 22433849
Host-derived proteases are crucial for the successful infection of vertebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi. B. burgdorferi must traverse tissue barriers in the tick...
7.
Elliott S, Riddick N, Francella N, Paiardini M, Vanderford T, Li B, et al.
J Virol
. 2011 Nov;
86(2):898-908.
PMID: 22090107
Natural host sooty mangabeys (SM) infected with simian immunodeficiency virus SIVsmm do not develop AIDS despite high viremia. SM and other natural hosts express very low levels of CCR5 on...
8.
Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz A, Chahroudi A, et al.
Nat Med
. 2011 Jun;
17(7):830-6.
PMID: 21706028
Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to AIDS despite high-level virus replication. We previously showed that the fraction of CD4(+)CCR5(+) T cells is lower in sooty...
9.
Clarke T, Francella N, Huegel A, Weiser J
Cell Host Microbe
. 2011 May;
9(5):404-14.
PMID: 21575911
Streptococcus pneumoniae and Haemophilus influenzae are members of the normal human nasal microbiota with the ability to cause invasive infections. Bacterial invasion requires translocation across the epithelium; however, mechanistic understanding...
10.
Bosinger S, Li Q, Gordon S, Klatt N, Duan L, Xu L, et al.
J Clin Invest
. 2009 Dec;
119(12):3556-72.
PMID: 19959874
Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques...