Nicholas E Propson
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Explore the profile of Nicholas E Propson including associated specialties, affiliations and a list of published articles.
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19
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2626
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Recent Articles
1.
Guo J, Braun D, Fitzgerald G, Hsieh Y, Rouge L, Litvinchuk A, et al.
Cell
. 2024 Nov;
188(1):187-206.e26.
PMID: 39532095
While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we...
2.
Gedam M, Comerota M, Propson N, Chen T, Jin F, Wang M, et al.
J Clin Invest
. 2023 Jun;
133(12).
PMID: 37317973
Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1...
3.
Jennings D, Huntwork-Rodriguez S, Henry A, Sasaki J, Meisner R, Diaz D, et al.
Sci Transl Med
. 2022 Jun;
14(648):eabj2658.
PMID: 35675433
Mutations in leucine-rich repeat kinase 2 () are the most common genetic risk factors for Parkinson's disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal function and may...
4.
Roy E, Chiu G, Li S, Propson N, Kanchi R, Wang B, et al.
Immunity
. 2022 Apr;
55(5):879-894.e6.
PMID: 35443157
The principal signals that drive memory and cognitive impairment in Alzheimer's disease (AD) remain elusive. Here, we revealed brain-wide cellular reactions to type I interferon (IFN-I), an innate immune cytokine...
5.
Xu Y, Propson N, Du S, Xiong W, Zheng H
Proc Natl Acad Sci U S A
. 2021 Jun;
118(27).
PMID: 34187889
The autophagy-lysosomal pathway plays a critical role in intracellular clearance and metabolic homeostasis. While neuronal autophagy is known to participate in the degradation of neurofibrillary tangles composed of hyperphosphorylated and...
6.
Ghosh A, Comerota M, Wan D, Chen F, Propson N, Hwang S, et al.
Sci Transl Med
. 2020 Dec;
12(573).
PMID: 33298560
Neuroinflammation has been increasingly recognized to play a critical role in Alzheimer's disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid metabolism pathway and have anti-inflammatory...
7.
Propson N, Gedam M, Zheng H
Annu Rev Pathol
. 2020 Nov;
16:277-298.
PMID: 33234021
Classic innate immune signaling pathways provide most of the immune response in the brain. This response activates many of the canonical signaling mechanisms identified in peripheral immune cells, despite their...
8.
Propson N, Roy E, Litvinchuk A, Kohl J, Zheng H
J Clin Invest
. 2020 Sep;
131(1).
PMID: 32990682
Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer disease; however, their interrelatedness remains poorly understood. The complement pathway is a well-established regulator of innate immunity...
9.
Roy E, Wang B, Wan Y, Chiu G, Cole A, Yin Z, et al.
J Clin Invest
. 2020 Jan;
130(4):1912-1930.
PMID: 31917687
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we demonstrated a potent IFN immunogenicity of nucleic acid-containing (NA-containing) amyloid fibrils in the...
10.
Litvinchuk A, Wan Y, Swartzlander D, Chen F, Cole A, Propson N, et al.
Neuron
. 2018 Nov;
100(6):1337-1353.e5.
PMID: 30415998
Strong evidence implicates the complement pathway as an important contributor to amyloid pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation remains unclear. Here we show...