Nicholas E Leadbeater
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Explore the profile of Nicholas E Leadbeater including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Nandi J, Leadbeater N
Org Biomol Chem
. 2019 Oct;
17(41):9182-9186.
PMID: 31595927
A mild and efficient route to prepare nitriles from aldehydes by combining photoredox catalysis with oxoammonium cations is reported. The reaction is performed using ammonium carbamate as the nitrogen source....
12.
Pistritto V, Paolillo J, Bisset K, Leadbeater N
Org Biomol Chem
. 2018 Jun;
16(25):4715-4719.
PMID: 29900460
We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of...
13.
Nandi J, Ovian J, Kelly C, Leadbeater N
Org Biomol Chem
. 2017 Sep;
15(39):8295-8301.
PMID: 28929164
We present a new paradigm for nitroxyl-mediated processes via the merger of oxoammonium cation-mediated oxidation with visible-light photoredox catalysis. The integration of these two forms of catalysis has been realised...
14.
Miller S, Bobbitt J, Leadbeater N
Org Biomol Chem
. 2017 Mar;
15(13):2817-2822.
PMID: 28281712
A systematic study of the oxidation of a range of terminal diols is reported, employing the oxoammonium salt 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (4-NHAc-TEMPO BF) as the oxidant. For substrates bearing a hydrocarbon...
15.
Ovian J, Kelly C, Pistritto V, Leadbeater N
Org Lett
. 2017 Mar;
19(6):1286-1289.
PMID: 28248527
An operationally simple, robust, metal-free approach to the synthesis of N-acyl azoles from both alcohols and aldehydes is described. Oxidative amidation is facilitated by a commercially available organic oxidant (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium...
16.
Loman J, Carnaghan E, Hamlin T, Ovian J, Kelly C, Mercadante M, et al.
Org Biomol Chem
. 2016 Apr;
14(16):3883-8.
PMID: 27031501
The propensity of oxoammonium cations to facilitate the oxidative ring-opening of cyclic ethers to their corresponding distal hydroxy ketones is investigated. The reaction has been evaluated using experimental and computational...
17.
Magpusao A, Rutledge K, Hamlin T, Lawrence J, Mercado B, Leadbeater N, et al.
Chemistry
. 2016 Mar;
22(17):6001-11.
PMID: 27001347
Shape is an inherent trait of a molecule that dictates how it interacts with other molecules, either in binding events or intermolecular reactions. Large-ring macrocyclic compounds in particular leverage their...
18.
Hamlin T, Leadbeater N
J Vis Exp
. 2015 Dec;
(105).
PMID: 26650190
By using inline monitoring, it is possible to optimize reactions performed using continuous-flow processing in a simple and rapid way. It is also possible to ensure consistent product quality over...
19.
Hamlin T, Kelly C, Ovian J, Wiles R, Tilley L, Leadbeater N
J Org Chem
. 2015 Jul;
80(16):8150-67.
PMID: 26167866
A range of oxoammonium salt-based oxidation reactions have been explored computationally using density functional theory (DFT), and the results have been correlated with experimentally derived trends in reactivity. Mechanistically, most...
20.
Kelly C, Ovian J, Cywar R, Gosselin T, Wiles R, Leadbeater N
Org Biomol Chem
. 2015 Mar;
13(14):4255-9.
PMID: 25748071
A method to oxidatively cleave allyl ethers to their corresponding aldehydes mediated by an oxoammonium salt is described. Using a biphasic solvent system and mild heating, cleavage proceeds readily, furnishing...