John M Ovian
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Explore the profile of John M Ovian including associated specialties, affiliations and a list of published articles.
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9
Citations
57
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Recent Articles
1.
Ovian J, Vojackova P, Jacobsen E
Nature
. 2023 Feb;
616(7955):84-89.
PMID: 36787801
Asymmetric transition-metal catalysis represents a powerful strategy for accessing enantiomerically enriched molecules. The classical strategy for inducing enantioselectivity with transition-metal catalysts relies on direct complexation of chiral ligands to produce...
2.
Levin M, Ovian J, Read J, Sigman M, Jacobsen E
J Am Chem Soc
. 2020 Aug;
142(35):14831-14837.
PMID: 32799536
We report an iodoarene-catalyzed enantioselective synthesis of β,β-difluoroalkyl bromide building blocks. The transformation involves an oxidative rearrangement of α-bromostyrenes, utilizing HF-pyridine as the fluoride source and -CPBA as the stoichiometric...
3.
4.
Nandi J, Ovian J, Kelly C, Leadbeater N
Org Biomol Chem
. 2017 Sep;
15(39):8295-8301.
PMID: 28929164
We present a new paradigm for nitroxyl-mediated processes via the merger of oxoammonium cation-mediated oxidation with visible-light photoredox catalysis. The integration of these two forms of catalysis has been realised...
5.
Ovian J, Kelly C, Pistritto V, Leadbeater N
Org Lett
. 2017 Mar;
19(6):1286-1289.
PMID: 28248527
An operationally simple, robust, metal-free approach to the synthesis of N-acyl azoles from both alcohols and aldehydes is described. Oxidative amidation is facilitated by a commercially available organic oxidant (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium...
6.
Loman J, Carnaghan E, Hamlin T, Ovian J, Kelly C, Mercadante M, et al.
Org Biomol Chem
. 2016 Apr;
14(16):3883-8.
PMID: 27031501
The propensity of oxoammonium cations to facilitate the oxidative ring-opening of cyclic ethers to their corresponding distal hydroxy ketones is investigated. The reaction has been evaluated using experimental and computational...
7.
Hamlin T, Kelly C, Ovian J, Wiles R, Tilley L, Leadbeater N
J Org Chem
. 2015 Jul;
80(16):8150-67.
PMID: 26167866
A range of oxoammonium salt-based oxidation reactions have been explored computationally using density functional theory (DFT), and the results have been correlated with experimentally derived trends in reactivity. Mechanistically, most...
8.
Kelly C, Ovian J, Cywar R, Gosselin T, Wiles R, Leadbeater N
Org Biomol Chem
. 2015 Mar;
13(14):4255-9.
PMID: 25748071
A method to oxidatively cleave allyl ethers to their corresponding aldehydes mediated by an oxoammonium salt is described. Using a biphasic solvent system and mild heating, cleavage proceeds readily, furnishing...
9.
Kelly C, Lambert K, Mercadante M, Ovian J, Bailey W, Leadbeater N
Angew Chem Int Ed Engl
. 2015 Feb;
54(14):4241-5.
PMID: 25665019
A scalable, high yielding, rapid route to access an array of nitriles from aldehydes mediated by an oxoammonium salt (4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) and hexamethyldisilazane (HMDS) as an ammonia surrogate has been...