Nicholas D E Greene
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Explore the profile of Nicholas D E Greene including associated specialties, affiliations and a list of published articles.
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130
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5126
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Recent Articles
1.
Drago P, Bookey N, Leung K, Henry M, Meleady P, Greene N, et al.
FASEB J
. 2025 Feb;
39(4):e70391.
PMID: 39957677
Dihydrofolate reductase activity is required in One Carbon Metabolism to ensure that the biologically active form of folate, tetrahydrofolate, is replenished and available as an enzyme cofactor for numerous cellular...
2.
Santos C, Marshall A, Murray A, Metcalfe K, Narayan P, de Castro S, et al.
Elife
. 2024 Dec;
12.
PMID: 39636098
Primary and secondary neurulation - processes that form the spinal cord - are incompletely understood in humans, largely due to the challenge of accessing neurulation-stage embryos (3-7 weeks post-conception). Here,...
3.
Leung K, Weston E, de Castro S, Nikolopoulou E, Sudiwala S, Savery D, et al.
FASEB J
. 2024 Jun;
38(11):e23738.
PMID: 38855924
Maternal nutrition contributes to gene-environment interactions that influence susceptibility to common congenital anomalies such as neural tube defects (NTDs). Supplemental myo-inositol (MI) can prevent NTDs in some mouse models and...
4.
Leung K, Santos C, de Castro S, Diaz D, Copp A, Waddington S, et al.
Mol Genet Metab
. 2024 May;
142(3):108496.
PMID: 38761651
Non-Ketotic Hyperglycinemia (NKH) is a rare inborn error of metabolism caused by impaired function of the glycine cleavage system (GCS) and characterised by accumulation of glycine in body fluids and...
5.
Bookey N, Drago P, Leung K, Hughes L, MacCooey A, Ozaki M, et al.
Mol Cell Proteomics
. 2024 Jan;
23(3):100718.
PMID: 38224738
A functional role has been ascribed to the human dihydrofolate reductase 2 (DHFR2) gene based on the enzymatic activity of recombinant versions of the predicted translated protein. However, the in ...
6.
Maniou E, Farah F, Marshall A, Crane-Smith Z, Krstevski A, Stathopoulou A, et al.
Development
. 2023 Sep;
150(19).
PMID: 37756583
Closed spinal dysraphisms are poorly understood malformations classified as neural tube (NT) defects. Several, including terminal myelocystocele, affect the distal spine. We have previously identified a NT closure-initiating point, Closure...
7.
Copp A, Clark M, Greene N
Front Cell Dev Biol
. 2023 Aug;
11:1223849.
PMID: 37601098
Morphological phenotyping of the mouse embryo is described at neurulation stages, primarily as a guide to evaluating the outcome of whole embryo cultures between embryonic days 8.5 and 9.5. During...
8.
Mohan H, Nguyen J, MacKenzie B, Yee A, Laurette E, Sanghvi T, et al.
EBioMedicine
. 2023 Aug;
95:104762.
PMID: 37586112
Background: Dolutegravir (DTG) is a recommended first-line regimen for all people with Human Immunodeficiency Virus (HIV) infection. Initial findings from Botswana, a country with no folate fortification program, showed an...
9.
Dontsova V, Mohan H, Blanco C, Jao J, Greene N, Copp A, et al.
Lancet HIV
. 2023 Aug;
10(9):e606-e616.
PMID: 37549681
Dolutegravir is recommended for all people living with HIV because of its efficacy, high barrier to resistance, favourable safety and tolerability profile, and affordability. Dolutegravir has the highest rates of...
10.
Lang M, Leung K, Greene N, Malone K, Saginc G, Randi A, et al.
Front Immunol
. 2023 Jul;
14:1209490.
PMID: 37457690
Objectives: The disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely understood....