Nicholas C Brecha
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Explore the profile of Nicholas C Brecha including associated specialties, affiliations and a list of published articles.
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54
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1605
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Recent Articles
1.
Matynia A, Recio B, Myers Z, Parikh S, Goit R, Brecha N, et al.
Invest Ophthalmol Vis Sci
. 2024 Jan;
65(1):28.
PMID: 38224335
Purpose: Intrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in non-image-forming visual functions. Given their significant loss observed in various ocular degenerative diseases at early stages, this study...
2.
Smith B, McHugh C, Hirano A, Brecha N, Barnes S
J Neurosci
. 2023 Feb;
43(13):2291-2304.
PMID: 36828637
Increasing spike rates drive greater neuronal energy demand. In turn, mitochondrial ATP production leads to the generation of reactive oxygen species (ROS) that can modulate ion channel gating. Does ROS...
3.
Chen A, Azar S, Harris A, Brecha N, Perez de Sevilla Muller L
Front Neuroanat
. 2021 Jun;
15:629244.
PMID: 34093139
Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease. In this study, we...
4.
Vesicular Release of GABA by Mammalian Horizontal Cells Mediates Inhibitory Output to Photoreceptors
Hirano A, Vuong H, Kornmann H, Schietroma C, Stella Jr S, Barnes S, et al.
Front Cell Neurosci
. 2020 Dec;
14:600777.
PMID: 33335476
Feedback inhibition by horizontal cells regulates rod and cone photoreceptor calcium channels that control their release of the neurotransmitter glutamate. This inhibition contributes to synaptic gain control and the formation...
5.
Barnes S, Grove J, McHugh C, Hirano A, Brecha N
Front Cell Neurosci
. 2020 Dec;
14:595064.
PMID: 33328894
How neurons in the eye feed signals back to photoreceptors to optimize sensitivity to patterns of light appears to be mediated by one or more unconventional mechanisms. Via these mechanisms,...
6.
Veldman M, Park C, Eyermann C, Zhang J, Zuniga-Sanchez E, Hirano A, et al.
Neuron
. 2020 Aug;
108(1):111-127.e6.
PMID: 32795398
Cajal recognized that the elaborate shape of neurons is fundamental to their function in the brain. However, there are no simple and generalizable genetic methods to study neuronal or glial...
7.
Burger C, Alevy J, Casasent A, Jiang D, Albrecht N, Liang J, et al.
Elife
. 2020 May;
9.
PMID: 32378514
Structural changes in pre and postsynaptic neurons that accompany synapse formation often temporally and spatially overlap. Thus, it has been difficult to resolve which processes drive patterned connectivity. To overcome...
8.
Zhang Y, Williams P, Jacobi A, Wang C, Goel A, Hirano A, et al.
Neuron
. 2019 May;
103(1):39-51.e5.
PMID: 31122676
Despite robust effects on immature neurons, growth factors minimally promote axon regeneration in the adult central nervous system (CNS). Attempting to improve growth-factor responsiveness in mature neurons by dedifferentiation, we...
9.
Grove J, Hirano A, de Los Santos J, McHugh C, Purohit S, Field G, et al.
PLoS Biol
. 2019 Apr;
17(4):e3000200.
PMID: 30933967
The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal...
10.
Hirano A, Liu X, Brecha N, Barnes S
Methods Mol Biol
. 2018 Mar;
1753:179-189.
PMID: 29564789
Genetic manipulation of horizontal cells using a Connexin57-iCre mouse (Cx57-iCre) line combined with calcium imaging is proving to be a valuable method to study horizontal cell feedback inhibition onto photoreceptor...