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Nicholas Borcherding

Explore the profile of Nicholas Borcherding including associated specialties, affiliations and a list of published articles. Areas
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Articles 75
Citations 2023
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Recent Articles
1.
Upadhye M, Wilhelm C, Rogers K, Vemulawada C, Borcherding N, Boyden A, et al.
J Neuroinflammation . 2025 Feb; 22(1):54. PMID: 40022134
Multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system, is modeled in mice as experimental autoimmune encephalomyelitis (EAE). While CD4 T cells, primarily Th1 and Th17 subsets,...
2.
Wang Y, Xiu Y, Dong Q, Zhao J, Neumbo K, Miyagi M, et al.
Blood Adv . 2024 Dec; 9(4):844-855. PMID: 39626355
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain B (TIFAB), an inhibitor of NF-κB signaling, plays critical roles in hematopoiesis, myelodysplastic neoplasms, and leukemia. We previously demonstrated...
3.
Corvino D, Batstone M, Hughes B, Kempchen T, Ng S, Salim N, et al.
Eur J Immunol . 2024 Nov; 55(1):e202451371. PMID: 39529512
Background: Head and neck squamous cell carcinoma (HNSCC) is linked to human papillomavirus (HPV) infection. HPV-positive and HPV-negative HNSCC exhibit distinct molecular and clinical characteristics. Although checkpoint inhibitors have shown...
4.
Kim M, Borcherding N, Song W, Kolb R, Zhang W
Front Vet Sci . 2024 Oct; 11:1434617. PMID: 39376916
Introduction: Single-cell RNA sequencing (scRNA-seq) has become an essential tool for uncovering the complexities of various physiological and immunopathological conditions in veterinary medicine. However, there is currently limited information on...
5.
Nakai R, Varnum S, Field R, Shi H, Giwa R, Jia W, et al.
Nat Metab . 2024 Sep; 6(10):1886-1896. PMID: 39223312
Mitochondria transfer is a recently described phenomenon in which donor cells deliver mitochondria to acceptor cells. One possible consequence of mitochondria transfer is energetic support of neighbouring cells; for example,...
6.
Borcherding N, Kim W, Quinn M, Han F, Zhou J, Sturtz A, et al.
Nat Immunol . 2024 Aug; 25(9):1731-1741. PMID: 39164479
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4 T cell responses. Using single-cell transcriptomics, here, we evaluated CD4 T cells specific for the SARS-CoV-2...
7.
Mazziotta F, Biavati L, Rimando J, Rutella S, Borcherding N, Parbhoo S, et al.
Blood . 2024 May; 144(11):1168-1182. PMID: 38776511
The interplay between T-cell states of differentiation, dysfunction, and treatment response in acute myeloid leukemia (AML) remains unclear. Here, we leveraged a multimodal approach encompassing high-dimensional flow cytometry and single-cell...
8.
Wang L, Maharjan C, Borcherding N, Master R, Mo J, Tithi T, et al.
bioRxiv . 2024 May; PMID: 38712046
Interleukin 2 (IL-2) is the first identified cytokine and its interaction with receptors has been known to shape the immune responses in many lymphoid or non-lymphoid tissues for more than...
9.
Kim M, De U, Borcherding N, Wang L, Paek J, Bhattacharyya I, et al.
Commun Biol . 2024 Apr; 7(1):481. PMID: 38641668
Childhood Sjögren's disease represents critically unmet medical needs due to a complete lack of immunological and molecular characterizations. This study presents key immune cell subsets and their interactions in the...
10.
Irac S, Soon M, Borcherding N, Tuong Z
Nat Methods . 2024 Apr; 21(5):777-792. PMID: 38637691
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell development to tracking clonal expansion...