Nicholas Arpaia
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Explore the profile of Nicholas Arpaia including associated specialties, affiliations and a list of published articles.
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4589
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Recent Articles
1.
Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee K, et al.
Nature
. 2025 Mar;
PMID: 40074890
Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood. Here we demonstrate that genetic depletion...
2.
Loffredo L, Kustagi A, Ringham O, Li F, de Los Santos-Alexis K, Saqi A, et al.
Nat Commun
. 2025 Mar;
16(1):2129.
PMID: 40032825
Amphiregulin (Areg), a growth factor produced by regulatory T (Treg) cells to facilitate tissue repair, contains a heparan sulfate (HS) binding domain. How HS, a highly sulfated glycan subtype that...
3.
Rouanne M, Chen N, Mariuzza D, Li F, de Los Santos-Alexis K, Savage T, et al.
bioRxiv
. 2024 Nov;
PMID: 39554157
The intratumoral microbiome has recently emerged as a new hallmark of cancer, with implications for response or resistance to therapy. While bacteria can either promote or inhibit cancer growth, intratumoral...
4.
Li F, Yang Z, Savage T, Vincent R, de Los Santos-Alexis K, Ahn A, et al.
Sci Immunol
. 2024 Oct;
9(100):eadn9879.
PMID: 39423284
Interferon-γ (IFN-γ) is a potent cytokine critical for response to immunotherapy, yet conventional methods to systemically deliver this cytokine have been hindered by severe dose-limiting toxicities. Here, we engineered a...
5.
Redenti A, Im J, Redenti B, Li F, Rouanne M, Sheng Z, et al.
Nature
. 2024 Oct;
635(8038):453-461.
PMID: 39415001
Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo. With emerging evidence that bacteria naturally home in on tumours and modulate antitumour immunity, one promising application is...
6.
Loffredo L, Kaiser K, Kornberg A, Rao S, de Los Santos-Alexis K, Han A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386607
Regulatory T (Treg) cells are known to play critical roles in tissue repair via provision of growth factors such as amphiregulin (Areg). Areg-producing Treg cells have previously been difficult to...
7.
Loffredo L, Savage T, Ringham O, Arpaia N
J Exp Med
. 2024 May;
221(6).
PMID: 38739114
No abstract available.
8.
Loffredo L, Surpur A, Ringham O, Li F, de Los Santos-Alexis K, Arpaia N
bioRxiv
. 2024 May;
PMID: 38712053
Amphiregulin (Areg), a growth factor produced by regulatory T (Treg) cells to facilitate tissue repair/regeneration, contains a heparan sulfate (HS) binding domain. How HS, a highly sulfated glycan subtype that...
9.
Loffredo L, Savage T, Ringham O, Arpaia N
J Exp Med
. 2024 Apr;
221(6).
PMID: 38668758
Regulatory T (Treg) cells are classically known for their critical immunosuppressive functions that support peripheral tolerance. More recent work has demonstrated that Treg cells produce pro-repair mediators independent of their...
10.
Vincent R, Li F, Ballister E, Arpaia N, Danino T
J Vis Exp
. 2024 Feb;
(204).
PMID: 38372353
Engineered cell therapies utilizing chimeric antigen receptor (CAR)-T cells have achieved remarkable effectiveness in individuals with hematological malignancies and are presently undergoing development for the treatment of diverse solid tumors....