Nicholas Arpaia
Overview
Explore the profile of Nicholas Arpaia including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
4589
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Recent Articles
11.
Savage T, Fortson K, de Los Santos-Alexis K, Oliveras-Alsina A, Rouanne M, Rae S, et al.
Immunity
. 2024 Feb;
57(2):303-318.e6.
PMID: 38309273
Production of amphiregulin (Areg) by regulatory T (Treg) cells promotes repair after acute tissue injury. Here, we examined the function of Treg cells in non-alcoholic steatohepatitis (NASH), a setting of...
12.
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Gurbatri C, Radford G, Vrbanac L, Im J, Thomas E, Coker C, et al.
Nat Commun
. 2024 Jan;
15(1):646.
PMID: 38245513
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli...
13.
Vincent R, Gurbatri C, Li F, Vardoshvili A, Coker C, Im J, et al.
Science
. 2023 Oct;
382(6667):211-218.
PMID: 37824640
A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)-T cells is the identification of suitable targets that are specifically and uniformly expressed on heterogeneous solid tumors....
14.
Chung R, McKiernan J, Arpaia N, Marabelle A, Rouanne M
Eur J Cancer
. 2023 Apr;
187:58-64.
PMID: 37116288
Bacillus Calmette-Guerin (BCG) is a live attenuated Mycobacterium bovis strain, originally developed as a vaccine against tuberculosis. It is also the only bacterial cancer therapy approved by the US Food...
15.
Gurbatri C, Radford G, Vrbanac L, Coker C, Im J, Taylor S, et al.
bioRxiv
. 2023 Apr;
PMID: 37066243
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery...
16.
Savage T, Vincent R, Rae S, Huang L, Ahn A, Pu K, et al.
Sci Adv
. 2023 Mar;
9(10):eadc9436.
PMID: 36888717
Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor immunity. Strategies to overcome these exclusion signals remain limited due to an inability to target therapeutics specifically to...
17.
Rankin L, Kaiser K, de Los Santos-Alexis K, Park H, Uhlemann A, Gray D, et al.
Cell Rep
. 2023 Feb;
42(3):112135.
PMID: 36840944
Micronutrient deficiency is a major cause of disease throughout the world. Yet, how perturbations influence the immune-microbiome interface remains poorly understood. Here, we report that loss of dietary tryptophan (Trp)...
18.
Kaiser K, Loffredo L, de Los Santos-Alexis K, Ringham O, Arpaia N
J Exp Med
. 2022 Dec;
220(3).
PMID: 36534084
Following respiratory viral infection, regeneration of the epithelial barrier is required to preserve lung function and prevent secondary infections. Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation...
19.
Gurbatri C, Arpaia N, Danino T
Science
. 2022 Nov;
378(6622):858-864.
PMID: 36423303
With increasing evidence that microbes colonize tumors, synthetic biology tools are being leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered systems can modulate the tumor microenvironment using a...
20.
Filliol A, Saito Y, Nair A, Dapito D, Yu L, Ravichandra A, et al.
Nature
. 2022 Oct;
610(7931):356-365.
PMID: 36198802
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide, develops almost exclusively in patients with chronic liver disease and advanced fibrosis. Here we interrogated functions of hepatic stellate...