Nelli Mnatsakanyan
Overview
Explore the profile of Nelli Mnatsakanyan including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
690
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Recent Articles
1.
Jonas E, Mnatsakanyan N, Rivera-Molina F, Robson A, MacColl Garfinkel A, Kumar A, et al.
Res Sq
. 2024 Sep;
PMID: 39315269
For mitochondrial metabolism to occur in the matrix, multiple proteins must be imported across the two (inner and outer) mitochondrial membranes. Classically, two protein import channels, TIM/TOM, are known to...
2.
MacColl Garfinkel A, Mnatsakanyan N, Patel J, Wills A, Shteyman A, Smith P, et al.
Dev Cell
. 2023 Sep;
58(22):2597-2613.e4.
PMID: 37673063
An instructive role for metabolism in embryonic patterning is emerging, although a role for mitochondria is poorly defined. We demonstrate that mitochondrial oxidative metabolism establishes the embryonic patterning center, the...
3.
Wu J, Mnatsakanyan N, Ji M
Front Aging Neurosci
. 2023 Aug;
15:1253644.
PMID: 37559678
No abstract available.
4.
Ponnusamy T, Velusamy P, Kumar A, Morris D, Zhang X, Ning G, et al.
Res Sq
. 2023 Jul;
PMID: 37502932
Calcium (Ca) uptake by mitochondria is essential in regulating bioenergetics, cell death, and cytosolic Ca transients. Mitochondrial Calcium Uniporter (MCU) mediates the mitochondrial Ca uptake. MCU is a heterooligomeric complex...
5.
Bernardi P, Gerle C, Halestrap A, Jonas E, Karch J, Mnatsakanyan N, et al.
Cell Death Differ
. 2023 Jul;
30(8):1869-1885.
PMID: 37460667
The mitochondrial permeability transition (mPT) describes a Ca-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It...
6.
Park H, Brown S, Jansen J, Dunn T, Scott M, Mnatsakanyan N, et al.
Biochem Biophys Res Commun
. 2022 Oct;
632:173-180.
PMID: 36209586
The presence of circulating cancer cells in the bloodstream is positively correlated with metastasis. We hypothesize that fluid shear stress (FSS) occurring during circulation alters mitochondrial function, enhancing metastatic behaviors...
7.
Mnatsakanyan N, Park H, Wu J, He X, Llaguno M, Latta M, et al.
Cell Death Differ
. 2022 Mar;
29(9):1874-1887.
PMID: 35322203
Mitochondrial ATP synthase is vital not only for cellular energy production but also for energy dissipation and cell death. ATP synthase c-ring was suggested to house the leak channel of...
8.
Li Y, Valdez N, Mnatsakanyan N, Weber J
Arch Biochem Biophys
. 2021 May;
707:108899.
PMID: 33991499
ATP synthase is essential in aerobic energy metabolism, and the rotary catalytic mechanism is one of the core concepts to understand the energetic functions of ATP synthase. Disulfide bonds formed...
9.
Licznerski P, Park H, Rolyan H, Chen R, Mnatsakanyan N, Miranda P, et al.
Cell
. 2020 Aug;
182(5):1170-1185.e9.
PMID: 32795412
Loss of the gene (Fmr1) encoding Fragile X mental retardation protein (FMRP) causes increased mRNA translation and aberrant synaptic development. We find neurons of the Fmr1 mouse have a mitochondrial...
10.
Mnatsakanyan N, Jonas E
Exp Neurol
. 2020 Jul;
332:113400.
PMID: 32653453
The mitochondrial FF ATP synthase is one of the most abundant proteins of the mitochondrial inner membrane, which catalyzes the final step of oxidative phosphorylation to synthesize ATP from ADP...