Nele Vanderroost
Overview
Explore the profile of Nele Vanderroost including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
147
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0
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Recent Articles
1.
Van Lint S, Van Parys A, Van Den Eeckhout B, Vandamme N, Plaisance S, Verhee A, et al.
Mol Cancer
. 2023 Nov;
22(1):191.
PMID: 38031106
Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major obstacle for the induction of efficient antitumor responses. In this study, we show that local delivery of...
2.
Huyghe L, Van Parys A, Cauwels A, Van Lint S, De Munter S, Bultinck J, et al.
EMBO Mol Med
. 2020 Jan;
12(2):e11223.
PMID: 31912630
Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity-on-Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index....
3.
Sachse S, Lievens S, Ribeiro L, Dascenco D, Masschaele D, Horre K, et al.
EMBO J
. 2019 Feb;
38(6).
PMID: 30745319
DSCAM and DSCAML1 are immunoglobulin and cell adhesion-type receptors serving important neurodevelopmental functions including control of axon growth, branching, neurite self-avoidance, and neuronal cell death. The signal transduction mechanisms or...
4.
Lievens S, Van der Heyden J, Masschaele D, De Ceuninck L, Petta I, Gupta S, et al.
Mol Cell Proteomics
. 2016 Nov;
15(12):3624-3639.
PMID: 27803151
Because proteins are the main mediators of most cellular processes they are also prime therapeutic targets. Identifying physical links among proteins and between drugs and their protein targets is essential...
5.
Lievens S, Gerlo S, Lemmens I, De Clercq D, Risseeuw M, Vanderroost N, et al.
Mol Cell Proteomics
. 2014 Aug;
13(12):3332-42.
PMID: 25154561
Probably every cellular process is governed by protein-protein interaction (PPIs), which are often highly dynamic in nature being modulated by in- or external stimuli. Here we present KISS, for KInase...
6.
Lievens S, Vanderroost N, Defever D, Van der Heyden J, Tavernier J
Methods Mol Biol
. 2012 Jan;
812:283-94.
PMID: 22218867
Mammalian protein-protein interaction trap (MAPPIT) is a two-hybrid technology to identify and characterize interactions of proteins with other proteins or organic molecules in living mammalian (human) cells. The method relies...
7.
Wauman J, De Ceuninck L, Vanderroost N, Lievens S, Tavernier J
J Cell Sci
. 2011 Mar;
124(Pt 6):921-32.
PMID: 21378310
Cytokines, such as interferons, erythropoietin, leptin and most interleukins, signal through type 1 cytokine receptors and activate the canonical JAK-STAT pathway. Aberrant cytokine signalling underlies numerous pathologies and adequate, temporary...
8.
Lievens S, Vanderroost N, Van der Heyden J, Gesellchen V, Vidal M, Tavernier J
J Proteome Res
. 2009 Jan;
8(2):877-86.
PMID: 19159283
Physical interactions between proteins play a key role in probably every cellular process. Efforts to chart the protein interaction networks are ongoing in a number of model organisms using a...