Nele Hug
Overview
Explore the profile of Nele Hug including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
801
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0
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Recent Articles
1.
Hug N, Aitken S, Longman D, Raab M, Armes H, Mann A, et al.
RNA
. 2022 Jun;
28(9):1224-1238.
PMID: 35768279
The DExD/H-box RNA helicase DHX34 is a nonsense-mediated decay (NMD) factor that together with core NMD factors coregulates NMD targets in nematodes and in vertebrates. Here, we show that DHX34...
2.
Lopez-Perrote A, Hug N, Gonzalez-Corpas A, Rodriguez C, Serna M, Garcia-Martin C, et al.
Elife
. 2020 Nov;
9.
PMID: 33205750
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an...
3.
Longman D, Jackson-Jones K, Maslon M, Murphy L, Young R, Stoddart J, et al.
Genes Dev
. 2020 Jul;
34(15-16):1075-1088.
PMID: 32616520
Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic...
4.
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, et al.
Nat Commun
. 2020 Feb;
11(1):1044.
PMID: 32098966
The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at...
5.
Fernandez N, Cordiner R, Young R, Hug N, Macias S, Caceres J
Nat Commun
. 2017 May;
8:15114.
PMID: 28466845
MiRNA biogenesis is highly regulated at the post-transcriptional level; however, the role of sequence and secondary RNA structure in this process has not been extensively studied. A single G to...
6.
Melero R, Hug N, Lopez-Perrote A, Yamashita A, Caceres J, Llorca O
Nat Commun
. 2016 Feb;
7:10585.
PMID: 26841701
Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase DHX34 was found to promote mRNP...
7.
Hug N, Longman D, Caceres J
Nucleic Acids Res
. 2016 Jan;
44(4):1483-95.
PMID: 26773057
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of...
8.
Casadio A, Longman D, Hug N, Delavaine L, Baier R, Alonso C, et al.
EMBO Rep
. 2014 Dec;
16(1):71-8.
PMID: 25452588
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the...
9.
Hug N, Caceres J
Cell Rep
. 2014 Sep;
8(6):1845-1856.
PMID: 25220460
Nonsense-mediated decay (NMD) is a surveillance mechanism that degrades aberrant mRNAs. A complex comprising SMG1, UPF1, and the translation termination factors eRF1 and eRF3 (SURF) is assembled in the vicinity...
10.
Longman D, Hug N, Keith M, Anastasaki C, Patton E, Grimes G, et al.
Nucleic Acids Res
. 2013 Jul;
41(17):8319-31.
PMID: 23828042
The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons but also regulates the abundance of cellular RNAs. We sought to identify transcripts that are regulated by...