Negin Holland
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Explore the profile of Negin Holland including associated specialties, affiliations and a list of published articles.
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28
Citations
494
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Recent Articles
11.
Luppi A, Mediano P, Rosas F, Holland N, Fryer T, OBrien J, et al.
Nat Neurosci
. 2022 May;
25(6):771-782.
PMID: 35618951
How does the organization of neural information processing enable humans' sophisticated cognition? Here we decompose functional interactions between brain regions into synergistic and redundant components, revealing their distinct information-processing roles....
12.
Ye R, OCallaghan C, Rua C, Hezemans F, Holland N, Malpetti M, et al.
Mov Disord
. 2022 May;
37(8):1663-1672.
PMID: 35576973
Background: Neurodegeneration in the locus coeruleus (LC) contributes to neuropsychiatric symptoms in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP). Spatial precision of LC imaging is improved with ultrahigh...
13.
Hezemans F, Wolpe N, OCallaghan C, Ye R, Rua C, Jones P, et al.
PLoS Comput Biol
. 2022 May;
18(5):e1010079.
PMID: 35533200
Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain...
14.
In Vivo F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy
Malpetti M, Kaalund S, Tsvetanov K, Rittman T, Briggs M, Allinson K, et al.
J Nucl Med
. 2021 Nov;
63(7):1052-1057.
PMID: 34795013
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by neuroglial tau pathology. A new staging system for PSP pathology postmortem has been described and validated. We used a data-driven...
15.
Mak E, Kouli A, Holland N, Nicastro N, Savulich G, Surendranathan A, et al.
Brain Commun
. 2021 Sep;
3(3):fcab177.
PMID: 34485906
While [F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of 'off-target' [F]-AV-1451 binding to neuromelanin in the substantia nigra...
16.
Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study
Holland N, Malpetti M, Rittman T, Mak E, Passamonti L, Kaalund S, et al.
Brain
. 2021 Aug;
145(1):340-348.
PMID: 34398211
The relationship between in vivo synaptic density and molecular pathology in primary tauopathies is key to understanding the impact of tauopathy on functional decline and in informing new early therapeutic...
17.
Rowe J, Holland N, Rittman T
Pract Neurol
. 2021 Jul;
21(5):376-383.
PMID: 34215700
Treating patients with progressive supranuclear palsy (PSP) is both effective and rewarding. This review aims to share our experience in the proactive management of PSP, considering the patient, the family...
18.
Malpetti M, Holland N, Jones P, Ye R, Cope T, Fryer T, et al.
Ann Clin Transl Neurol
. 2021 Jun;
8(7):1515-1523.
PMID: 34133849
Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [ C]UCB-J PET...
19.
OCallaghan C, Hezemans F, Ye R, Rua C, Jones P, Murley A, et al.
Brain
. 2021 Mar;
144(8):2513-2526.
PMID: 33783470
Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic...
20.
Holland N, Robbins T, Rowe J
Brain
. 2021 Mar;
144(8):2243-2256.
PMID: 33725122
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is...