Ned B Smith
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Explore the profile of Ned B Smith including associated specialties, affiliations and a list of published articles.
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4
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64
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Recent Articles
1.
Bendaly J, Doll M, Millner L, Metry K, Smith N, Pierce Jr W, et al.
Mutat Res
. 2009 Aug;
671(1-2):13-9.
PMID: 19682468
Aromatic amines such as 4-aminobiphenyl (ABP) require biotransformation to exert their carcinogenic effects. Genetic polymorphisms in biotransformation enzymes such as N-acetyltransferase 2 (NAT2) may modify cancer risk following exposure. Nucleotide...
2.
Metry K, Neale J, Bendaly J, Smith N, Pierce Jr W, Hein D
Drug Metab Dispos
. 2009 Aug;
37(11):2123-6.
PMID: 19666988
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) are suspected human carcinogens generated in well done meats. After N-hydroxylation, they are O-acetylated by N-acetyltransferase 2 (NAT2) to electrophiles that form DNA adducts. dG-C8-MeIQx...
3.
Neale J, Smith N, Pierce W, Hein D
Polycycl Aromat Compd
. 2009 Jan;
28(4-5):402-417.
PMID: 19122802
Xenobiotic-DNA adducts are used as biomarkers to assess the genotoxic effects of carcinogens. Rats were dosed with 4-aminobiphenyl (4-ABP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). DNA was isolated from the colons...
4.
Neale J, Richter N, Merten K, Taylor K, Singh S, Waite L, et al.
Bioorg Med Chem Lett
. 2009 Jan;
19(3):680-3.
PMID: 19117754
In this study a novel bone-targeting agent containing elements of the tricarbonylmethane system of ring A of tetracycline was developed and was shown to bind to the mineral constituent of...