Nathaniel B Fernhoff
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Explore the profile of Nathaniel B Fernhoff including associated specialties, affiliations and a list of published articles.
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13
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2088
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Recent Articles
1.
Bader C, Pavlova A, Lowsky R, Muffly L, Shiraz P, Arai S, et al.
Blood Adv
. 2023 Dec;
8(5):1105-1115.
PMID: 38091578
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for hematological malignancies for which graft-versus-host disease (GVHD) remains a major complication. The use of donor T-regulatory cells (Tregs) to prevent...
2.
Tsai J, Shoham M, Fernhoff N, George B, Marjon K, McCracken M, et al.
Blood Adv
. 2019 Sep;
3(18):2713-2721.
PMID: 31519647
Peritoneal adhesions are pathological fibroses that ensnare organs after abdominal surgery. This dense connective tissue can cause small bowel obstruction, female infertility, and chronic abdominal pain. The pathogenesis of adhesions...
3.
Loh K, Chen A, Koh P, Deng T, Sinha R, Tsai J, et al.
Cell
. 2016 Jul;
166(2):451-467.
PMID: 27419872
Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiation toward desired fates....
4.
Bennett M, Bennett F, Liddelow S, Ajami B, Zamanian J, Fernhoff N, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(12):E1738-46.
PMID: 26884166
The specific function of microglia, the tissue resident macrophages of the brain and spinal cord, has been difficult to ascertain because of a lack of tools to distinguish microglia from...
5.
Fathman J, Fernhoff N, Seita J, Chao C, Scarfone V, Weissman I, et al.
Stem Cell Reports
. 2014 Nov;
3(5):707-15.
PMID: 25418718
Small numbers of hematopoietic stem cells (HSCs) generate large numbers of mature effector cells through the successive amplification of transiently proliferating progenitor cells. HSCs and their downstream progenitors have been...
6.
Weiskopf K, Ring A, Ho C, Volkmer J, Levin A, Volkmer A, et al.
Science
. 2013 Jun;
341(6141):88-91.
PMID: 23722425
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction. Here, we modified the binding domain of human SIRPα, the receptor for CD47, for use as a...
7.
Tseng D, Volkmer J, Willingham S, Contreras-Trujillo H, Fathman J, Fernhoff N, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(27):11103-8.
PMID: 23690610
Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting cells optimally to achieve an effective antitumor...
8.
Inlay M, Choe V, Bharathi S, Fernhoff N, Baker Jr J, Weissman I, et al.
Chem Commun (Camb)
. 2013 Apr;
49(43):4971-3.
PMID: 23612712
We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.
9.
Fernhoff N, Derbyshire E, Underbakke E, Marletta M
J Biol Chem
. 2012 Oct;
287(51):43053-62.
PMID: 23093402
Nitric oxide (NO) signaling regulates key processes in cardiovascular physiology, specifically vasodilation, platelet aggregation, and leukocyte rolling. Soluble guanylate cyclase (sGC), the mammalian NO sensor, transduces an NO signal into...
10.
Smith B, Fernhoff N, Marletta M
Biochemistry
. 2012 Jan;
51(5):1028-40.
PMID: 22242685
Nitric oxide (NO), the product of the nitric oxide synthase (NOS) reaction, was previously shown to result in S-nitrosation of the NOS Zn(2+)-tetrathiolate and inactivation of the enzyme. To probe...