Nathan W Goehring
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Explore the profile of Nathan W Goehring including associated specialties, affiliations and a list of published articles.
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31
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1321
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Recent Articles
1.
Rodrigues N, Bland T, Ng K, Hirani N, Goehring N
PLoS Biol
. 2024 Dec;
22(12):e3002437.
PMID: 39652540
A key challenge in the development of an organism is to maintain robust phenotypic outcomes in the face of perturbation. Yet, it is often unclear how such robust outcomes are...
2.
Bland T, Hirani N, Briggs D, Rossetto R, Ng K, Taylor I, et al.
EMBO J
. 2024 Jun;
43(15):3214-3239.
PMID: 38907033
Cell polarity networks are defined by quantitative features of their constituent feedback circuits, which must be tuned to enable robust and stable polarization, while also ensuring that networks remain responsive...
3.
Ng K, Hirani N, Bland T, Borrego-Pinto J, Wagner S, Kreysing M, et al.
Curr Biol
. 2023 Sep;
33(20):4298-4311.e6.
PMID: 37729912
During development, the conserved PAR polarity network is continuously redeployed, requiring that it adapt to changing cellular contexts and environmental cues. In the early C. elegans embryo, polarity shifts from...
4.
Illukkumbura R, Hirani N, Borrego-Pinto J, Bland T, Ng K, Hubatsch L, et al.
J Cell Biol
. 2023 Jun;
222(8).
PMID: 37265444
Clustering of membrane-associated molecules is thought to promote interactions with the actomyosin cortex, enabling size-dependent transport by actin flows. Consistent with this model, in the Caenorhabditis elegans zygote, efficient anterior...
5.
Ng K, Bland T, Hirani N, Goehring N
MicroPubl Biol
. 2022 Aug;
2022.
PMID: 35996692
Engineered analog sensitive kinases provide a highly effective method for acute, controllable, and highly selective inhibition of kinase activity. Here we describe the design and characterization of an analog sensitive...
6.
Rodrigues N, Bland T, Borrego-Pinto J, Ng K, Hirani N, Gu Y, et al.
Development
. 2022 Jun;
149(14).
PMID: 35713287
Biological systems are increasingly viewed through a quantitative lens that demands accurate measures of gene expression and local protein concentrations. CRISPR/Cas9 gene tagging has enabled increased use of fluorescence to...
7.
Delattre M, Goehring N
Curr Top Dev Biol
. 2021 May;
144:269-308.
PMID: 33992156
Starting with Boveri in the 1870s, microscopic investigation of early embryogenesis in a broad swath of nematode species revealed the central role of asymmetric cell division in embryonic axis specification,...
8.
Hubatsch L, Goehring N
Curr Top Dev Biol
. 2020 Mar;
137:247-278.
PMID: 32143745
The notion that graded distributions of signals underlie the spatial organization of biological systems has long been a central pillar in the fields of cell and developmental biology. During morphogenesis,...
9.
Illukkumbura R, Bland T, Goehring N
Curr Opin Cell Biol
. 2019 Nov;
62:123-134.
PMID: 31760155
Beginning with Turing's seminal work [1], decades of research have demonstrated the fundamental ability of biochemical networks to generate and sustain the formation of patterns. However, it is increasingly appreciated...
10.
Hubatsch L, Peglion F, Reich J, Rodrigues N, Hirani N, Illukkumbura R, et al.
Nat Phys
. 2019 Oct;
15(10):1075-1085.
PMID: 31579399
Reaction-diffusion networks underlie pattern formation in a range of biological contexts, from morphogenesis of organisms to the polarisation of individual cells. One requirement for such molecular networks is that output...