Nathan W Goehring
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Explore the profile of Nathan W Goehring including associated specialties, affiliations and a list of published articles.
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31
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1321
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Recent Articles
11.
Gross P, Kumar K, Goehring N, Bois J, Hoege C, Julicher F, et al.
Nat Phys
. 2019 Jul;
15(3):293-300.
PMID: 31327978
Spontaneous pattern formation in Turing systems relies on feedback. Patterns in cells and tissues however often do not form spontaneously, but are under control of upstream pathways that provide molecular...
12.
Peglion F, Goehring N
Curr Opin Cell Biol
. 2019 Jul;
60:121-130.
PMID: 31295650
Polarity is defined by the segregation of cellular components along a defined axis. To polarize robustly, cells must be able to break symmetry and subsequently amplify these nascent asymmetries. Finally,...
13.
Hirani N, Illukkumbura R, Bland T, Mathonnet G, Suhner D, Reymann A, et al.
J Cell Sci
. 2019 Jun;
132(14).
PMID: 31221727
The association of molecules within membrane microdomains is critical for the intracellular organization of cells. During polarization of the zygote, both polarity proteins and actomyosin regulators associate within dynamic membrane-associated...
14.
Reich J, Hubatsch L, Illukkumbura R, Peglion F, Bland T, Hirani N, et al.
Curr Biol
. 2019 Jun;
29(12):1911-1923.e5.
PMID: 31155349
How do cells polarize at the correct time and in response to the correct cues? In the C. elegans zygote, the timing and geometry of polarization rely on a single...
15.
Rodriguez J, Peglion F, Martin J, Hubatsch L, Reich J, Hirani N, et al.
Dev Cell
. 2017 Aug;
42(4):400-415.e9.
PMID: 28781174
The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical protein kinase C (aPKC) form a core unit of the PAR protein network, which plays a central role in polarizing...
16.
Reber S, Goehring N
Cold Spring Harb Perspect Biol
. 2015 Aug;
7(12).
PMID: 26254310
Organelle function is often directly related to organelle size. However, it is not necessarily absolute size but the organelle-to-cell-size ratio that is critical. Larger cells generally have increased metabolic demands,...
17.
Goehring N
Exp Cell Res
. 2014 Aug;
328(2):258-66.
PMID: 25128809
The par-titioning-defective or PAR proteins comprise the core of an essential cell polarity network that underlies polarization in a wide variety of cell types and developmental contexts. The output of...
18.
Goehring N, Grill S
Trends Cell Biol
. 2012 Nov;
23(2):72-80.
PMID: 23182746
Nearly every cell type exhibits some form of polarity, yet the molecular mechanisms vary widely. Here we examine what we term 'chemical systems' where cell polarization arises through biochemical interactions...
19.
Goehring N, Hyman A
Curr Biol
. 2012 May;
22(9):R330-9.
PMID: 22575475
The critical importance of controlling the size and number of intracellular organelles has led to a variety of mechanisms for regulating the formation and growth of cellular structures. In this...
20.
Goehring N, Khuc Trong P, Bois J, Chowdhury D, Nicola E, Hyman A, et al.
Science
. 2011 Oct;
334(6059):1137-41.
PMID: 22021673
In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR) polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of the cortical actomyosin meshwork. The...