Nathan L Ponzar
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Explore the profile of Nathan L Ponzar including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
56
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0
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Recent Articles
1.
Tajwar R, Bradley D, Ponzar N, Tavis J
Protein Sci
. 2022 Sep;
31(10):e4421.
PMID: 36173165
Hepatitis B virus (HBV) chronically infects >250 million people. It replicates by a unique protein-primed reverse transcription mechanism, and the primary anti-HBV drugs are nucleos(t)ide analogs targeting the viral polymerase...
2.
Ponzar N, Tajwar R, Pozzi N, Tavis J
J Biol Chem
. 2022 Mar;
298(4):101790.
PMID: 35247386
The ribonucleases H (RNases H) of HIV and hepatitis B virus are type 1 RNases H that are promising drug targets because inhibiting their activity blocks viral replication. Eukaryotic ribonuclease...
3.
Bradley D, ODea A, Woodson M, Li Q, Ponzar N, Knier A, et al.
Antimicrob Agents Chemother
. 2021 Oct;
66(1):e0161721.
PMID: 34694883
The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV) replication that can target HBV RNase H with submicromolar efficacies. αHTs and related troponoids (tropones and tropolones) can be...
4.
Li Q, Edwards T, Ponzar N, Tavis J
J Virol Methods
. 2021 Mar;
292:114127.
PMID: 33766659
The hepatitis B virus (HBV) ribonuclease H (RNaseH) is a promising but unexploited drug target. Inhibiting the RNaseH blocks viral reverse transcription by truncating the minus-polarity DNA strand, causing accumulation...
5.
Edwards T, Ponzar N, Tavis J
Expert Opin Ther Targets
. 2019 May;
23(7):559-563.
PMID: 31084514
No abstract available.
6.
Long K, Lomonosova E, Li Q, Ponzar N, Villa J, Touchette E, et al.
Antiviral Res
. 2017 Nov;
149:41-47.
PMID: 29129708
Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the hepatitis B virus ribonuclease H that...