Nathan L Alderson
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Explore the profile of Nathan L Alderson including associated specialties, affiliations and a list of published articles.
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21
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1127
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Recent Articles
1.
Alderson N, Hama H
J Lipid Res
. 2009 Jan;
50(6):1203-8.
PMID: 19171550
Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids contain 2-hydroxy fatty acids, produced by fatty acid 2-hydroxylase (FA2H),...
2.
Ponnusamy S, Alderson N, Hama H, Bielawski J, Jiang J, Bhandari R, et al.
J Biol Chem
. 2008 Aug;
283(41):27514-27524.
PMID: 18694931
In this study, we investigated the roles of very long-chain fatty acid (VLCFA) synthesis by fatty acid elongase 3 (ELO3) in the regulation of telomere length and life span in...
3.
FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin
Maldonado E, Alderson N, Monje P, Wood P, Hama H
J Lipid Res
. 2007 Sep;
49(1):153-61.
PMID: 17901466
Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids. We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by...
4.
Uchida Y, Hama H, Alderson N, Douangpanya S, Wang Y, Crumrine D, et al.
J Biol Chem
. 2007 Mar;
282(18):13211-9.
PMID: 17355976
Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of molecular species that subserve the epidermal permeability barrier, an essential function for survival in a terrestrial environment. In addition to...
5.
Vasireddy V, Uchida Y, Salem Jr N, Kim S, Mandal M, Reddy G, et al.
Hum Mol Genet
. 2007 Jan;
16(5):471-82.
PMID: 17208947
Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss...
6.
Alderson N, Maldonado E, Kern M, Bhat N, Hama H
J Lipid Res
. 2006 Sep;
47(12):2772-80.
PMID: 16998236
2-Hydroxy fatty acids are relatively minor species of membrane lipids found almost exclusively as N-acyl chains of sphingolipids. In mammals, 2-hydroxy sphingolipids are uniquely abundant in myelin galactosylceramide and sulfatide....
7.
Alderson N, Wang Y, Blatnik M, Frizzell N, Walla M, Lyons T, et al.
Arch Biochem Biophys
. 2006 Apr;
450(1):1-8.
PMID: 16624247
S-(2-Succinyl)cysteine (2SC) has been identified as a chemical modification in plasma proteins, in the non-mercaptalbumin fraction of human plasma albumin, in human skin collagen, and in rat skeletal muscle proteins...
8.
Alderson N, Walla M, Hama H
J Lipid Res
. 2005 May;
46(7):1569-75.
PMID: 15863841
Fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is an enzyme responsible for the de novo synthesis of sphingolipids containing 2-hydroxy fatty acids. 2-Hydroxy sphingolipids are highly abundant in...
9.
Januszewski A, Alderson N, Jenkins A, Thorpe S, Baynes J
J Lipid Res
. 2005 Apr;
46(7):1440-9.
PMID: 15805546
Chemical modification of proteins by advanced glycation and lipoxidation end products is implicated in the pathogenesis of macrovascular disease in aging and diabetes. To identify biomarkers of the lipoxidative modification...
10.
Forbes J, Thomas M, Thorpe S, Alderson N, Cooper M
Kidney Int Suppl
. 2004 Oct;
(92):S105-7.
PMID: 15485399
Background: Blockade of the RAS with the ACE inhibitor ramipril prevents the accumulation of advanced glycation end products (AGEs) in experimental diabetes. Although AT1 receptor antagonists may inhibit AGE formation...