Jennifer Tickner
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Explore the profile of Jennifer Tickner including associated specialties, affiliations and a list of published articles.
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66
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1545
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Recent Articles
1.
Kenny J, Mullin B, Tomlinson W, Robertson B, Yuan J, Chen W, et al.
Arthritis Res Ther
. 2023 Dec;
25(1):232.
PMID: 38041181
Objectives: Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in...
2.
Chen K, Liao S, Li Y, Jiang H, Liu Y, Wang C, et al.
Theranostics
. 2021 Nov;
11(20):9738-9751.
PMID: 34815781
Angiogenesis and osteogenesis are highly coupled processes which are indispensable to bone repair. However, the underlying mechanism(s) remain elusive. To bridge the gap in understanding the coupling process is crucial...
3.
Anderson D, Skut P, Hughes A, Ferrari E, Tickner J, Xu J, et al.
Sci Rep
. 2020 Nov;
10(1):19173.
PMID: 33154494
The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains...
4.
Qiu H, Qin A, Cheng T, Chim S, Smithers L, Chen K, et al.
J Cell Physiol
. 2020 Sep;
236(4):2800-2816.
PMID: 32964459
The tumor necrosis factor (TNF)-like core domain of receptor activator of nuclear factor-κB ligand (RANKL) is a functional domain critical for osteoclast differentiation. One of the missense mutations identified in...
5.
Li S, Liu Q, Wu D, He T, Yuan J, Qiu H, et al.
Cell Death Dis
. 2020 Sep;
11(9):762.
PMID: 32938907
PKC-δ is an important molecule for B-cell proliferation and tolerance. B cells have long been recognized to play a part in osteoimmunology and pathological bone loss. However, the role of...
6.
Li S, He T, Wu D, Zhang L, Chen R, Liu B, et al.
Front Cell Dev Biol
. 2020 Jun;
8:450.
PMID: 32582715
Protein kinase C delta (PKC-δ) functions as an important regulator in bone metabolism. However, the precise involvement of PKC-δ in the regulation of osteoclasts remains elusive. We generated an osteoclast...
7.
Hong G, Zhou L, Han X, Sun P, Chen Z, He W, et al.
Front Pharmacol
. 2020 Apr;
11:331.
PMID: 32292339
is a triterpenoid compound extracted from a medicinal plant . It has been used as a highly efficient compound for the treatment of cancer and hyperlipidemia, as well as possessing...
8.
Mullin B, Tickner J, Zhu K, Kenny J, Mullin S, Brown S, et al.
Genome Biol
. 2020 Mar;
21(1):80.
PMID: 32216834
Background: Osteoporosis is a complex disease with a strong genetic contribution. A recently published genome-wide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genome-wide significant association...
9.
Yuan Y, Chen K, Chen X, Wang C, Qiu H, Cao Z, et al.
Front Pharmacol
. 2020 Mar;
11:238.
PMID: 32210820
Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one...
10.
Zhou L, Hong G, Li S, Liu Q, Song F, Zhao J, et al.
Int J Biol Sci
. 2020 Jan;
16(2):309-319.
PMID: 31929758
Osteoporosis is a disease characterized by abnormally increased formation and function of osteoclasts. Anti-RANKL treatment using natural medicine is a potential therapy for osteoporosis. Here, we studied the effect of...