Nathan E Lewis
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Explore the profile of Nathan E Lewis including associated specialties, affiliations and a list of published articles.
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181
Citations
8108
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Recent Articles
21.
Rawson R, Duong L, Tkachenko E, Chiang A, Okamoto K, Dohil R, et al.
Mucosal Immunol
. 2024 Feb;
17(3):315-322.
PMID: 38423390
The gastrointestinal system is a hollow organ affected by fibrostenotic diseases that cause volumetric compromise of the lumen via smooth muscle hypertrophy and fibrosis. Many of the driving mechanisms remain...
22.
Gopalakrishnan S, Johnson W, Valderrama-Gomez M, Icten E, Tat J, Ingram M, et al.
Metab Eng
. 2024 Feb;
82:183-192.
PMID: 38387677
Metabolism governs cell performance in biomanufacturing, as it fuels growth and productivity. However, even in well-controlled culture systems, metabolism is dynamic, with shifting objectives and resources, thus limiting the predictive...
23.
Liang C, Murray S, Li Y, Lee R, Low A, Sasaki S, et al.
Metab Eng
. 2024 Feb;
82:110-122.
PMID: 38311182
Lipid metabolism is a complex and dynamic system involving numerous enzymes at the junction of multiple metabolic pathways. Disruption of these pathways leads to systematic dyslipidemia, a hallmark of many...
24.
Lewis N, Aceves S
J Allergy Clin Immunol
. 2024 Jan;
153(3):669-671.
PMID: 38262501
No abstract available.
25.
Armingol E, Baghdassarian H, Lewis N
Nat Rev Genet
. 2024 Jan;
25(6):381-400.
PMID: 38238518
No cell lives in a vacuum, and the molecular interactions between cells define most phenotypes. Transcriptomics provides rich information to infer cell-cell interactions and communication, thus accelerating the discovery of...
26.
Baghdassarian H, Lewis N
Biotechnol Adv
. 2024 Jan;
71:108305.
PMID: 38215956
Cells execute biological functions to support phenotypes such as growth, migration, and secretion. Complementarily, each function of a cell has resource costs that constrain phenotype. Resource allocation by a cell...
27.
Masson H, Samoudi M, Robinson C, Kuo C, Weiss L, Shams Ud Doha K, et al.
Metab Eng
. 2023 Dec;
81:273-285.
PMID: 38145748
Understanding protein secretion has considerable importance in biotechnology and important implications in a broad range of normal and pathological conditions including development, immunology, and tissue function. While great progress has...
28.
Pong A, Mah C, Yeo G, Lewis N
Curr Opin Biotechnol
. 2023 Dec;
85:103048.
PMID: 38142648
Complex networks of cell-cell interactions (CCIs) within the tumor microenvironment (TME) play a crucial role in cancer persistence. These communication axes represent prime targets for therapeutic intervention, but our incomplete...
29.
Siddharth T, Lewis N
J Theor Biol
. 2023 Dec;
578:111684.
PMID: 38048983
The diverse metabolic pathways are fundamental to all living organisms, as they harvest energy, synthesize biomass components, produce molecules to interact with the microenvironment, and neutralize toxins. While the discovery...
30.
Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections
Gomez Toledo A, Bratanis E, Velasquez E, Chowdhury S, Olofsson B, Sorrentino J, et al.
Nat Commun
. 2023 Oct;
14(1):6693.
PMID: 37872209
Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here...