Nathan E Lewis
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Explore the profile of Nathan E Lewis including associated specialties, affiliations and a list of published articles.
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181
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8108
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Recent Articles
11.
Pessentheiner A, Spann N, Autran C, Oh T, Grunddal K, Coker J, et al.
JCI Insight
. 2024 Sep;
9(21).
PMID: 39325548
Macrophages contribute to the induction and resolution of inflammation and play a central role in chronic low-grade inflammation in cardiovascular diseases caused by atherosclerosis. Human milk oligosaccharides (HMOs) are complex...
12.
Hefzi H, Martinez-Monge I, Marin de Mas I, Cowie N, Gomez Toledo A, Noh S, et al.
bioRxiv
. 2024 Aug;
PMID: 39211256
The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to...
13.
Gopalakrishnan S, Johnson W, Valderrama-Gomez M, Icten E, Tat J, Lay F, et al.
Metab Eng
. 2024 Jul;
85:94-104.
PMID: 39047894
Characterizing the phenotypic diversity and metabolic capabilities of industrially relevant manufacturing cell lines is critical to bioprocess optimization and cell line development. Metabolic capabilities of production hosts limit nutrient and...
14.
Lin W, Chiang A, Zhou E, Liang C, Liu C, Ma W, et al.
bioRxiv
. 2024 Jun;
PMID: 38826229
Numerous biological processes and diseases are influenced by lipid composition. Advances in lipidomics are elucidating their roles, but analyzing and interpreting lipidomics data at the systems level remain challenging. To...
15.
Kellman B, Mariethoz J, Zhang Y, Shaul S, Alteri M, Sandoval D, et al.
bioRxiv
. 2024 May;
PMID: 38798633
Glycosylation is described as a non-templated biosynthesis. Yet, the template-free premise is antithetical to the observation that different N-glycans are consistently placed at specific sites. It has been proposed that...
16.
Yom A, Chiang A, Lewis N
Anal Chem
. 2024 May;
96(21):8332-8341.
PMID: 38720429
Glycans are complex oligosaccharides that are involved in many diseases and biological processes. Unfortunately, current methods for determining glycan composition and structure (glycan sequencing) are laborious and require a high...
17.
Baghdassarian H, Dimitrov D, Armingol E, Saez-Rodriguez J, Lewis N
Cell Rep Methods
. 2024 Apr;
4(4):100758.
PMID: 38631346
In recent years, data-driven inference of cell-cell communication has helped reveal coordinated biological processes across cell types. Here, we integrate two tools, LIANA and Tensor-cell2cell, which, when combined, can deploy...
18.
Li H, Peralta A, Schoffelen S, Hansen A, Arnsdorf J, Schinn S, et al.
bioRxiv
. 2024 Apr;
PMID: 38585977
Glycosylation affects many vital functions of organisms. Therefore, its surveillance is critical from basic science to biotechnology, including biopharmaceutical development and clinical diagnostics. However, conventional glycan structure analysis faces challenges...
19.
Rocamora F, Schoffelen S, Arnsdorf J, Toth E, Abdul Y, Cleveland 4th T, et al.
bioRxiv
. 2024 Apr;
PMID: 38585818
Alpha-1-antitrypsin (A1AT) is a multifunctional, clinically important, high value therapeutic glycoprotein that can be used for the treatment of many diseases such as alpha-1-antitrypsin deficiency, diabetes, graft-versus-host-disease, cystic fibrosis and...
20.
Park S, Choi D, Song J, Lakshmanan M, Richelle A, Yoon S, et al.
Trends Biotechnol
. 2024 Mar;
42(9):1192-1203.
PMID: 38548556
Genome-scale metabolic models (GEMs) of Chinese hamster ovary (CHO) cells are valuable for gaining mechanistic understanding of mammalian cell metabolism and cultures. We provide a comprehensive overview of past and...