Nathalie Eysackers
Overview
Explore the profile of Nathalie Eysackers including associated specialties, affiliations and a list of published articles.
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10
Citations
307
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Recent Articles
1.
De Smet V, Gurbuz E, Eysackers N, Dewyse L, Smout A, Dastjerd M, et al.
JHEP Rep
. 2024 May;
6(5):101036.
PMID: 38694958
Background & Aims: Chronic liver disease (CLD) remains a global health issue associated with a significant disease burden. Liver fibrosis, a hallmark of CLD, is characterised by the activation of...
2.
Mannaerts I, Eysackers N, van Grunsven L
Methods Mol Biol
. 2023 May;
2669:193-206.
PMID: 37247061
In vitro models of liver fibrosis have evolved from mono-cultures of primary rodent hepatic stellate cells and stellate cell lines, to more complex co-cultures of primary or stem cell-derived liver...
3.
van Os E, Cools L, Eysackers N, Szafranska K, Smout A, Verhulst S, et al.
Biomaterials
. 2022 Oct;
290:121817.
PMID: 36208587
Chronic liver disease can lead to liver fibrosis and ultimately cirrhosis, which is a significant health burden and a major cause of death worldwide. Reliable in vitro models are lacking...
4.
Dewyse L, De Smet V, Verhulst S, Eysackers N, Kunda R, Messaoudi N, et al.
Front Med (Lausanne)
. 2022 Apr;
9:862185.
PMID: 35433753
models of human liver disease often fail to mimic the complex 3D structures and cellular organizations found . Precision cut liver slices (PCLS) retain the complex physiological architecture of the...
5.
De Smet V, Eysackers N, Merens V, Dastjerd M, Halder G, Verhulst S, et al.
Cell Death Dis
. 2021 Nov;
12(12):1110.
PMID: 34839349
Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates...
6.
Verhulst S, van Os E, De Smet V, Eysackers N, Mannaerts I, van Grunsven L
Front Med (Lausanne)
. 2021 Nov;
8:750044.
PMID: 34746184
Liver sinusoidal endothelial cells have a gatekeeper function in liver homeostasis by permitting substrates from the bloodstream into the space of Disse and regulating hepatic stellate cell activation status. Maintenance...
7.
Mannaerts I, Eysackers N, van Os E, Verhulst S, Roosens T, Smout A, et al.
Biomaterials
. 2020 Sep;
261:120335.
PMID: 32891040
A major obstacle in the development of efficient therapies for progressive liver fibrosis is the lack of representative in vitro models of liver fibrosis to aid in understanding the mechanisms...
8.
Mannaerts I, Thoen L, Eysackers N, Cubero F, Batista Leite S, Coldham I, et al.
Cell Death Dis
. 2019 Feb;
10(2):98.
PMID: 30718473
Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix proteins. A drastic increase in matrix proteins results in liver fibrosis and we...
9.
Mannaerts I, Batista Leite S, Verhulst S, Claerhout S, Eysackers N, Thoen L, et al.
J Hepatol
. 2015 Apr;
63(3):679-88.
PMID: 25908270
Background & Aims: Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the...
10.
Mannaerts I, Eysackers N, Onyema O, Van Beneden K, Valente S, Mai A, et al.
PLoS One
. 2013 Feb;
8(1):e55786.
PMID: 23383282
Background: The conversion of a quiescent vitamin A storing hepatic stellate cell (HSC) to a matrix producing, contractile myofibroblast-like activated HSC is a key event in the onset of liver...