Ayla Smout
Overview
Explore the profile of Ayla Smout including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
150
Followers
0
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Recent Articles
1.
Cools L, Dastjerd M, Smout A, Merens V, Yang Y, Reynaert H, et al.
Biofabrication
. 2024 Jun;
16(3).
PMID: 38865994
The lack of adequate humanmodels that recapitulate the cellular composition and response of the human liver to injury hampers the development of anti-fibrotic drugs. The goal of this study was...
2.
De Smet V, Gurbuz E, Eysackers N, Dewyse L, Smout A, Dastjerd M, et al.
JHEP Rep
. 2024 May;
6(5):101036.
PMID: 38694958
Background & Aims: Chronic liver disease (CLD) remains a global health issue associated with a significant disease burden. Liver fibrosis, a hallmark of CLD, is characterised by the activation of...
3.
van Os E, Cools L, Eysackers N, Szafranska K, Smout A, Verhulst S, et al.
Biomaterials
. 2022 Oct;
290:121817.
PMID: 36208587
Chronic liver disease can lead to liver fibrosis and ultimately cirrhosis, which is a significant health burden and a major cause of death worldwide. Reliable in vitro models are lacking...
4.
Vallverdu J, Martinez Garcia de la Torre R, Mannaerts I, Verhulst S, Smout A, Coll M, et al.
Nat Protoc
. 2021 Apr;
16(5):2542-2563.
PMID: 33864055
Hepatic stellate cells (HSCs) are nonparenchymal liver cells responsible for extracellular matrix homeostasis and are the main cells involved in the development of liver fibrosis following injury. The lack of...
5.
De Smedt J, van Os E, Talon I, Ghosh S, Toprakhisar B, da Costa R, et al.
Cell Death Dis
. 2021 Jan;
12(1):84.
PMID: 33446637
To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth...
6.
Mannaerts I, Eysackers N, van Os E, Verhulst S, Roosens T, Smout A, et al.
Biomaterials
. 2020 Sep;
261:120335.
PMID: 32891040
A major obstacle in the development of efficient therapies for progressive liver fibrosis is the lack of representative in vitro models of liver fibrosis to aid in understanding the mechanisms...
7.
Coll M, Perea L, Boon R, Leite S, Vallverdu J, Mannaerts I, et al.
Cell Stem Cell
. 2018 Jul;
23(1):101-113.e7.
PMID: 30049452
The development of complex in vitro hepatic systems and artificial liver devices has been hampered by the lack of reliable sources for relevant cell types, such as hepatic stellate cells...